{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Joyce LR"],"funding":["NIAID NIH HHS","NINDS NIH HHS"],"pagination":["eadn7848"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11135403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(22)"],"pubmed_abstract":["<i>Streptococcus agalactiae</i> [group B <i>Streptococcus</i> (GBS)] is a leading cause of neonatal meningitis, with late-onset disease (LOD) occurring after gastrointestinal tract colonization in infants. Bacterial membrane lipids are essential for host-pathogen interactions, and the functions of glycolipids are yet to be fully elucidated. GBS synthesizes three major glycolipids: glucosyl-diacylglycerol (Glc-DAG), diglucosyl-DAG (Glc<sub>2</sub>-DAG), and lysyl-Glc-DAG (Lys-Glc-DAG). Here, we identify the enzyme, IagB, as responsible for biosynthesis of Glc-DAG, the precursor for the two other glycolipids in GBS. To examine the collective role of glycolipids to GBS virulence, we adapted a murine model of neonatal meningitis to simulate LOD. The GBS∆<i>iagB</i> mutant traversed the gut-epi"],"journal":["Science advances"],"pubmed_title":["&lt;i&gt;Streptococcus agalactiae&lt;/i&gt; glycolipids promote virulence by thwarting immune cell clearance."],"pmcid":["PMC11135403"],"funding_grant_id":["R01 AI153332","R01 AI178692","R01 NS116716","R01 NS098273","R01 AI148366"],"pubmed_authors":["Kim S","Doran KS","Guan Z","Christensen PM","Joyce LR","Spencer BL","Palmer KL","Siegenthaler JA"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Streptococcus agalactiae&lt;/i&gt; glycolipids promote virulence by thwarting immune cell clearance.","description":"<i>Streptococcus agalactiae</i> [group B <i>Streptococcus</i> (GBS)] is a leading cause of neonatal meningitis, with late-onset disease (LOD) occurring after gastrointestinal tract colonization in infants. Bacterial membrane lipids are essential for host-pathogen interactions, and the functions of glycolipids are yet to be fully elucidated. GBS synthesizes three major glycolipids: glucosyl-diacylglycerol (Glc-DAG), diglucosyl-DAG (Glc<sub>2</sub>-DAG), and lysyl-Glc-DAG (Lys-Glc-DAG). Here, we identify the enzyme, IagB, as responsible for biosynthesis of Glc-DAG, the precursor for the two other glycolipids in GBS. To examine the collective role of glycolipids to GBS virulence, we adapted a murine model of neonatal meningitis to simulate LOD. The GBS∆<i>iagB</i> mutant traversed the gut-epi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-03-11T00:06:06.503Z","creation":"2025-08-13T03:04:16.446Z"},"accession":"S-EPMC11135403","cross_references":{"pubmed":["38809989"],"doi":["10.1126/sciadv.adn7848"]}}