{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang T"],"funding":["Jiangsu Agricultural Science and Technology Innovation Fund","Open Funding of the Xuyi Center of Attapulgite Applied Technology Research Development &amp; Industrialization","National Key R&amp;D Program","he Guidance Foundation, the Sanya Institute of Nanjing Agricultural University Research"],"pagination":["120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11137985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>The Porcine Epidemic Diarrhea Virus (PEDV) has caused significant economic losses in the global swine industry. As a potential drug for treating diarrhea, the antiviral properties of attapulgite deserve further study.<h4>Methods</h4>In this study, various methods such as RT-qPCR, Western blot, viral titer assay, Cytopathic Effect, immunofluorescence analysis and transmission electron microscopy were used to detect the antiviral activity of attapulgite and to assess its inhibitory effect on PEDV.<h4>Results</h4>When exposed to the same amount of virus, there was a significant decrease in the expression of the S protein, resulting in a viral titer reduction from 10<sup>-5.613</sup> TCID<sub>50</sub>/mL to 10<sup>-2.90</sup> TCID<sub>50</sub>/mL, which represents a decrease"],"journal":["Virology journal"],"pubmed_title":["Virological evaluation of natural and modified attapulgite against porcine epidemic diarrhoea virus."],"pmcid":["PMC11137985"],"funding_grant_id":["2021YFD1800500","CX(21)2038","NAUSY-ZD08"],"pubmed_authors":["Wen Y","Xue F","Wang A","Wang T","Zhang X","Qian B","Xu X","Zhou Y","Tang F","Dai J"],"additional_accession":[]},"is_claimable":false,"name":"Virological evaluation of natural and modified attapulgite against porcine epidemic diarrhoea virus.","description":"<h4>Background</h4>The Porcine Epidemic Diarrhea Virus (PEDV) has caused significant economic losses in the global swine industry. As a potential drug for treating diarrhea, the antiviral properties of attapulgite deserve further study.<h4>Methods</h4>In this study, various methods such as RT-qPCR, Western blot, viral titer assay, Cytopathic Effect, immunofluorescence analysis and transmission electron microscopy were used to detect the antiviral activity of attapulgite and to assess its inhibitory effect on PEDV.<h4>Results</h4>When exposed to the same amount of virus, there was a significant decrease in the expression of the S protein, resulting in a viral titer reduction from 10<sup>-5.613</sup> TCID<sub>50</sub>/mL to 10<sup>-2.90</sup> TCID<sub>50</sub>/mL, which represents a decrease","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-03T01:32:13.202Z","creation":"2026-04-22T03:13:29.932Z"},"accession":"S-EPMC11137985","cross_references":{"pubmed":["38816738"],"doi":["10.1186/s12985-024-02396-w"]}}