{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Newcomb LF"],"funding":["NCI NIH HHS"],"pagination":["2084-2093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11140579"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["331(24)"],"pubmed_abstract":["<h4>Importance</h4>Outcomes from protocol-directed active surveillance for favorable-risk prostate cancers are needed to support decision-making.<h4>Objective</h4>To characterize the long-term oncological outcomes of patients receiving active surveillance in a multicenter, protocol-directed cohort.<h4>Design, setting, and participants</h4>The Canary Prostate Active Surveillance Study (PASS) is a prospective cohort study initiated in 2008. A cohort of 2155 men with favorable-risk prostate cancer and no prior treatment were enrolled at 10 North American centers through August 2022.<h4>Exposure</h4>Active surveillance for prostate cancer.<h4>Main outcomes and measures</h4>Cumulative incidence of biopsy grade reclassification, treatment, metastasis, prostate cancer mortality, overall mortality"],"journal":["JAMA"],"pubmed_title":["Long-Term Outcomes in Patients Using Protocol-Directed Active Surveillance for Prostate Cancer."],"pmcid":["PMC11140579"],"funding_grant_id":["U01 CA113913","P30 CA015704","P50 CA097186","U01 CA224255"],"pubmed_authors":["McKenney JK","Zheng Y","Brooks JD","Liu M","Dash A","Lin DW","Gleave ME","Wagner AA","Carroll PR","de la Calle CM","Martin F","Newcomb LF","Zhu K","Liss MA","Filson CP","Nelson PS","Schenk JM","Ellis WJ","Tretiakova MS","Morgan TM"],"additional_accession":[]},"is_claimable":false,"name":"Long-Term Outcomes in Patients Using Protocol-Directed Active Surveillance for Prostate Cancer.","description":"<h4>Importance</h4>Outcomes from protocol-directed active surveillance for favorable-risk prostate cancers are needed to support decision-making.<h4>Objective</h4>To characterize the long-term oncological outcomes of patients receiving active surveillance in a multicenter, protocol-directed cohort.<h4>Design, setting, and participants</h4>The Canary Prostate Active Surveillance Study (PASS) is a prospective cohort study initiated in 2008. A cohort of 2155 men with favorable-risk prostate cancer and no prior treatment were enrolled at 10 North American centers through August 2022.<h4>Exposure</h4>Active surveillance for prostate cancer.<h4>Main outcomes and measures</h4>Cumulative incidence of biopsy grade reclassification, treatment, metastasis, prostate cancer mortality, overall mortality","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-02T03:48:44.301Z","creation":"2026-04-14T03:12:29.32Z"},"accession":"S-EPMC11140579","cross_references":{"pubmed":["38814624"],"doi":["10.1001/jama.2024.6695"]}}