{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["118(2)"],"submitter":["Sadeghi P"],"funding":["Isfahan University of Medical Sciences"],"pubmed_abstract":["<i>Pseudomonas aeruginosa</i> has different antibiotic resistance pathways, such as broad-spectrum lactamases and metallo-β-lactamases (MBL), penicillin-binding protein (PBP) alteration, and active efflux pumps. Polymerase chain reaction (PCR) and sequencing methods were applied for double-locus sequence typing (DLST) and New Delhi metallo-β-lactamase (NDM) typing. We deduced the evolutionary pathways for DLST and NDM genes of P. aeruginosa using phylogenetic network. Among the analyzed isolates, 62.50% of the <i>P. aeruginosa</i> isolates were phenotypically carbapenem resistance (CARBR) isolates. Characterization of isolates revealed that the prevalence of bla<sub>NDM</sub>, bla<sub>VIM</sub>, bla<sub>IMP</sub>, undetermined carbapenemase, and MexAB-OprM were 27.5%, 2%, 2.5%, 12.5%, and "],"journal":["Pathogens and global health"],"pagination":["170-181"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141312"],"repository":["biostudies-literature"],"pubmed_title":["Evolutionary trajectories of beta-lactamase NDM and DLST cluster in <i>Pseudomonas aeruginosa</i>: finding the putative ancestor."],"pmcid":["PMC11141312"],"pubmed_authors":["Salari-Jazi A","Aspatwar A","Mahnam K","Faghri J","Sadeghi P"],"additional_accession":[]},"is_claimable":false,"name":"Evolutionary trajectories of beta-lactamase NDM and DLST cluster in <i>Pseudomonas aeruginosa</i>: finding the putative ancestor.","description":"<i>Pseudomonas aeruginosa</i> has different antibiotic resistance pathways, such as broad-spectrum lactamases and metallo-β-lactamases (MBL), penicillin-binding protein (PBP) alteration, and active efflux pumps. Polymerase chain reaction (PCR) and sequencing methods were applied for double-locus sequence typing (DLST) and New Delhi metallo-β-lactamase (NDM) typing. We deduced the evolutionary pathways for DLST and NDM genes of P. aeruginosa using phylogenetic network. Among the analyzed isolates, 62.50% of the <i>P. aeruginosa</i> isolates were phenotypically carbapenem resistance (CARBR) isolates. Characterization of isolates revealed that the prevalence of bla<sub>NDM</sub>, bla<sub>VIM</sub>, bla<sub>IMP</sub>, undetermined carbapenemase, and MexAB-OprM were 27.5%, 2%, 2.5%, 12.5%, and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-26T08:04:12.324Z","creation":"2025-04-06T12:35:05.561Z"},"accession":"S-EPMC11141312","cross_references":{"pubmed":["37464884"],"doi":["10.1080/20477724.2023.2236416"]}}