{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elfstrum AK"],"funding":["HHS | National Institutes of Health","NCATS NIH HHS","NICHD NIH HHS","HHS | National Institutes of Health (NIH)","NIAID NIH HHS","NCI NIH HHS"],"pagination":["1380-1397"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(5)"],"pubmed_abstract":["Macrophages represent a heterogeneous myeloid population with diverse functions in normal tissues and tumors. While macrophages expressing the cell surface marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) have been identified in stromal regions of the normal mammary gland and in the peritumoral stroma, their functions within these regions are not well understood. Using a genetic mouse model of LYVE-1+ macrophage depletion, we demonstrate that loss of LYVE-1+ macrophages is associated with altered extracellular matrix remodeling in the normal mammary gland and reduced mammary tumor growth in vivo. In further studies focused on investigating the functions of LYVE-1+ macrophages in the tumor microenvironment, we demonstrate that LYVE-1 expression correlates with an increased"],"journal":["Cancer research communications"],"pubmed_title":["LYVE-1-expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor Growth."],"pmcid":["PMC11141485"],"funding_grant_id":["UL1 TR002494","R01 CA265004","R01CA265004","R01 CA215052","R01CA215052","T32AI007313","T32 AI007313","R01HD95858","R01 HD095858","R01 HD106929","R01HD106929"],"pubmed_authors":["McCluskey BM","Reese LE","Rumahorbo AH","Schwertfeger KL","Elfstrum AK","Nelson EV"],"additional_accession":[]},"is_claimable":false,"name":"LYVE-1-expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor Growth.","description":"Macrophages represent a heterogeneous myeloid population with diverse functions in normal tissues and tumors. While macrophages expressing the cell surface marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) have been identified in stromal regions of the normal mammary gland and in the peritumoral stroma, their functions within these regions are not well understood. Using a genetic mouse model of LYVE-1+ macrophage depletion, we demonstrate that loss of LYVE-1+ macrophages is associated with altered extracellular matrix remodeling in the normal mammary gland and reduced mammary tumor growth in vivo. In further studies focused on investigating the functions of LYVE-1+ macrophages in the tumor microenvironment, we demonstrate that LYVE-1 expression correlates with an increased","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T06:54:54.393Z","creation":"2026-04-15T03:15:19.725Z"},"accession":"S-EPMC11141485","cross_references":{"pubmed":["38717149"],"doi":["10.1158/2767-9764.CRC-24-0205"]}}