biostudies-literatureElfstrum AKHHS | National Institutes of HealthNCATS NIH HHSNICHD NIH HHSHHS | National Institutes of Health (NIH)NIAID NIH HHSNCI NIH HHS1380-1397https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141485biostudies-literatureUnknown4(5)Macrophages represent a heterogeneous myeloid population with diverse functions in normal tissues and tumors. While macrophages expressing the cell surface marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) have been identified in stromal regions of the normal mammary gland and in the peritumoral stroma, their functions within these regions are not well understood. Using a genetic mouse model of LYVE-1+ macrophage depletion, we demonstrate that loss of LYVE-1+ macrophages is associated with altered extracellular matrix remodeling in the normal mammary gland and reduced mammary tumor growth in vivo. In further studies focused on investigating the functions of LYVE-1+ macrophages in the tumor microenvironment, we demonstrate that LYVE-1 expression correlates with an increasedCancer research communicationsLYVE-1-expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor Growth.PMC11141485UL1 TR002494R01 CA265004R01CA265004R01 CA215052R01CA215052T32AI007313T32 AI007313R01HD95858R01 HD095858R01 HD106929R01HD106929McCluskey BMReese LERumahorbo AHSchwertfeger KLElfstrum AKNelson EVfalseLYVE-1-expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor Growth.Macrophages represent a heterogeneous myeloid population with diverse functions in normal tissues and tumors. While macrophages expressing the cell surface marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) have been identified in stromal regions of the normal mammary gland and in the peritumoral stroma, their functions within these regions are not well understood. Using a genetic mouse model of LYVE-1+ macrophage depletion, we demonstrate that loss of LYVE-1+ macrophages is associated with altered extracellular matrix remodeling in the normal mammary gland and reduced mammary tumor growth in vivo. In further studies focused on investigating the functions of LYVE-1+ macrophages in the tumor microenvironment, we demonstrate that LYVE-1 expression correlates with an increased2024-01-01T00:00:00Z2024 May2026-06-02T06:54:54.393Z2026-04-15T03:15:19.725ZS-EPMC111414853871714910.1158/2767-9764.CRC-24-0205