biostudies-literatureUnknown15Liviero F<h4>Introduction</h4>Prior investigations into post-COVID dysautonomia often lacked control groups or compared affected individuals solely to healthy volunteers. In addition, no data on the follow-up of patients with SARS-CoV-2-related autonomic imbalance are available.<h4>Methods</h4>In this study, we conducted a comprehensive clinical and functional follow-up on healthcare workers (HCWs) with former mild COVID-19 (group 1, n = 67), to delineate the trajectory of post-acute autonomic imbalance, we previously detected in a case-control study. Additionally, we assessed HCWs for which a test before SARS-CoV-2 infection was available (group 2, n = 29), who later contracted SARS-CoV-2, aiming to validate findings from our prior case-control investigation. We evaluated autonomic nervous system Frontiers in neurology1403551https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141692biostudies-literatureLong term follow-up of heart rate variability in healthcare workers with mild COVID-19.PMC11141692Fabris LMason PFolino FLiviero FScapellato MLMoretto APavanello SVolpin ABrischigliaro LBattistella MfalseLong term follow-up of heart rate variability in healthcare workers with mild COVID-19.<h4>Introduction</h4>Prior investigations into post-COVID dysautonomia often lacked control groups or compared affected individuals solely to healthy volunteers. In addition, no data on the follow-up of patients with SARS-CoV-2-related autonomic imbalance are available.<h4>Methods</h4>In this study, we conducted a comprehensive clinical and functional follow-up on healthcare workers (HCWs) with former mild COVID-19 (group 1, n = 67), to delineate the trajectory of post-acute autonomic imbalance, we previously detected in a case-control study. Additionally, we assessed HCWs for which a test before SARS-CoV-2 infection was available (group 2, n = 29), who later contracted SARS-CoV-2, aiming to validate findings from our prior case-control investigation. We evaluated autonomic nervous system 2024-01-01T00:00:00Z20242026-03-17T16:09:45.264Z2025-08-18T09:53:01.089ZS-EPMC111416923882757610.3389/fneur.2024.1403551