{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kelly CM"],"funding":["NHLBI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["e178131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["The polymerization of myosin molecules into thick filaments in muscle sarcomeres is essential for cardiac contractility, with the attenuation of interactions between the heads of myosin molecules within the filaments being proposed to result in hypercontractility, as observed in hypertrophic cardiomyopathy (HCM). However, experimental evidence demonstrates that the structure of these giant macromolecular complexes is highly dynamic, with molecules exchanging between the filaments and a pool of soluble molecules on the minute timescale. Therefore, we sought to test the hypothesis that the enhancement of interactions between the heads of myosin molecules within thick filaments limits the mobility of myosin by taking advantage of mavacamten, a small molecule approved for the treatment of HCM."],"journal":["JCI insight"],"pubmed_title":["Myosin folding boosts solubility in cardiac muscle sarcomeres."],"pmcid":["PMC11141871"],"funding_grant_id":["T32 HL076122","R01 HL157487","P20 GM135007","R01-HL157487,T32-HL076122,1P20-GM135007"],"pubmed_authors":["Previs MJ","Kelly CM","Martin JL"],"additional_accession":[]},"is_claimable":false,"name":"Myosin folding boosts solubility in cardiac muscle sarcomeres.","description":"The polymerization of myosin molecules into thick filaments in muscle sarcomeres is essential for cardiac contractility, with the attenuation of interactions between the heads of myosin molecules within the filaments being proposed to result in hypercontractility, as observed in hypertrophic cardiomyopathy (HCM). However, experimental evidence demonstrates that the structure of these giant macromolecular complexes is highly dynamic, with molecules exchanging between the filaments and a pool of soluble molecules on the minute timescale. Therefore, we sought to test the hypothesis that the enhancement of interactions between the heads of myosin molecules within thick filaments limits the mobility of myosin by taking advantage of mavacamten, a small molecule approved for the treatment of HCM.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-02T10:33:37.047Z","creation":"2026-05-26T03:06:40.516Z"},"accession":"S-EPMC11141871","cross_references":{"pubmed":["38483507"],"doi":["10.1172/jci.insight.178131"]}}