{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(10)"],"submitter":["Ma G"],"pubmed_abstract":["The homeostasis of IgG is maintained by the neonatal Fc receptor, FcRn. Consequently, antagonism of FcRn to reduce endogenous IgG levels is an emerging strategy for treating antibody-mediated autoimmune disorders using either FcRn-specific antibodies or an engineered Fc fragment. For certain FcRn-specific antibodies, this approach has resulted in reductions in the levels of serum albumin, the other major ligand transported by FcRn. Cellular and molecular analyses of a panel of FcRn antagonists have been carried out to elucidate the mechanisms leading to their differential effects on albumin homeostasis. These analyses have identified 2 processes underlying decreases in albumin levels during FcRn blockade: increased degradation of FcRn and competition between antagonist and albumin for FcRn"],"journal":["JCI insight"],"pagination":["e176166"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141909"],"repository":["biostudies-literature"],"pubmed_title":["Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin."],"pmcid":["PMC11141909"],"pubmed_authors":["Crowley AR","Hofman E","Bobkov V","Ward ES","de Haard H","Heyndrickx L","Rogiers I","Van Santbergen J","Ober RJ","Louagie E","Parthoens E","Ulrichts P","Balbino B","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin.","description":"The homeostasis of IgG is maintained by the neonatal Fc receptor, FcRn. Consequently, antagonism of FcRn to reduce endogenous IgG levels is an emerging strategy for treating antibody-mediated autoimmune disorders using either FcRn-specific antibodies or an engineered Fc fragment. For certain FcRn-specific antibodies, this approach has resulted in reductions in the levels of serum albumin, the other major ligand transported by FcRn. Cellular and molecular analyses of a panel of FcRn antagonists have been carried out to elucidate the mechanisms leading to their differential effects on albumin homeostasis. These analyses have identified 2 processes underlying decreases in albumin levels during FcRn blockade: increased degradation of FcRn and competition between antagonist and albumin for FcRn","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T01:37:30.321Z","creation":"2026-04-13T03:12:24.934Z"},"accession":"S-EPMC11141909","cross_references":{"pubmed":["38713534"],"doi":["10.1172/jci.insight.176166"]}}