{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Whately KM"],"funding":["NIDCR NIH HHS","NCI NIH HHS"],"pagination":["e168792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11141919"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["Lung cancer is the leading cause of cancer-related deaths in the world, and non-small cell lung cancer (NSCLC) is the most common subset. We previously found that infiltration of tumor inflammatory monocytes (TIMs) into lung squamous carcinoma (LUSC) tumors is associated with increased metastases and poor survival. To further understand how TIMs promote metastases, we compared RNA-Seq profiles of TIMs from several LUSC metastatic models with inflammatory monocytes (IMs) of non-tumor-bearing controls. We identified Spon1 as upregulated in TIMs and found that Spon1 expression in LUSC tumors corresponded with poor survival and enrichment of collagen extracellular matrix signatures. We observed SPON1+ TIMs mediate their effects directly through LRP8 on NSCLC cells, which resulted in TGF-β1 act"],"journal":["JCI insight"],"pubmed_title":["Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling."],"pmcid":["PMC11141919"],"funding_grant_id":["R41 CA246848","R01 DE030123","P30 CA016086","R01 CA215075","R01 CA258451","T32 CA244125","F30 CA250189"],"pubmed_authors":["Yacovone G","Kim DJ","Porrello A","Sengottuvel N","Amelio AL","Dudley AC","Srivastava S","Jefferys SR","Edatt L","Woods AT","Pecot CV","Zimmerman MP","Tsai YS","Whately KM","Chack AC"],"additional_accession":[]},"is_claimable":false,"name":"Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling.","description":"Lung cancer is the leading cause of cancer-related deaths in the world, and non-small cell lung cancer (NSCLC) is the most common subset. We previously found that infiltration of tumor inflammatory monocytes (TIMs) into lung squamous carcinoma (LUSC) tumors is associated with increased metastases and poor survival. To further understand how TIMs promote metastases, we compared RNA-Seq profiles of TIMs from several LUSC metastatic models with inflammatory monocytes (IMs) of non-tumor-bearing controls. We identified Spon1 as upregulated in TIMs and found that Spon1 expression in LUSC tumors corresponded with poor survival and enrichment of collagen extracellular matrix signatures. We observed SPON1+ TIMs mediate their effects directly through LRP8 on NSCLC cells, which resulted in TGF-β1 act","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T06:17:02.242Z","creation":"2026-04-15T03:15:22.79Z"},"accession":"S-EPMC11141919","cross_references":{"pubmed":["38716730"],"doi":["10.1172/jci.insight.168792"]}}