{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Fanelli G"],"funding":["NIMH NIH HHS"],"pubmed_abstract":["The brain's default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. In the present study, we examined the genetic relationship between sociability and DMN-related resting-state functional magnetic resonance imaging (rs-fMRI) traits. To this end, we used genome-wide association summary statistics for sociability and 31 activity and 64 connectivity DMN-related rs-fMRI traits (N=34,691-342,461). First, we examined global and local genetic correlations between sociability and the rs-fMRI traits. Second, to assess putatively causal relationships between the traits, we conducted bi-directional Mendelian randomisation (MR) analyses. Finally, we prioritised genes influencing both soci"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.05.24.24307883"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142265"],"repository":["biostudies-literature"],"pubmed_title":["Shared genetics linking sociability with the brain's default mode network."],"pmcid":["PMC11142265"],"funding_grant_id":["R01 MH124851"],"pubmed_authors":["Fabbri C","Arenella M","Robinson J","Kas M","Bralten J","Roth Mota N","Serretti A","Sprooten E","Franke B","Fanelli G","Andlauer TF"],"additional_accession":[]},"is_claimable":false,"name":"Shared genetics linking sociability with the brain's default mode network.","description":"The brain's default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. In the present study, we examined the genetic relationship between sociability and DMN-related resting-state functional magnetic resonance imaging (rs-fMRI) traits. To this end, we used genome-wide association summary statistics for sociability and 31 activity and 64 connectivity DMN-related rs-fMRI traits (N=34,691-342,461). First, we examined global and local genetic correlations between sociability and the rs-fMRI traits. Second, to assess putatively causal relationships between the traits, we conducted bi-directional Mendelian randomisation (MR) analyses. Finally, we prioritised genes influencing both soci","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-08T06:04:09.856Z","creation":"2026-04-07T22:50:58.112Z"},"accession":"S-EPMC11142265","cross_references":{"pubmed":["38826220"],"doi":["10.1101/2024.05.24.24307883"]}}