biostudies-literatureUnknownFanelli GNIMH NIH HHSThe brain's default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. In the present study, we examined the genetic relationship between sociability and DMN-related resting-state functional magnetic resonance imaging (rs-fMRI) traits. To this end, we used genome-wide association summary statistics for sociability and 31 activity and 64 connectivity DMN-related rs-fMRI traits (N=34,691-342,461). First, we examined global and local genetic correlations between sociability and the rs-fMRI traits. Second, to assess putatively causal relationships between the traits, we conducted bi-directional Mendelian randomisation (MR) analyses. Finally, we prioritised genes influencing both socimedRxiv : the preprint server for health sciences2024.05.24.24307883https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142265biostudies-literatureShared genetics linking sociability with the brain's default mode network.PMC11142265R01 MH124851Fabbri CArenella MRobinson JKas MBralten JRoth Mota NSerretti ASprooten EFranke BFanelli GAndlauer TFfalseShared genetics linking sociability with the brain's default mode network.The brain's default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. In the present study, we examined the genetic relationship between sociability and DMN-related resting-state functional magnetic resonance imaging (rs-fMRI) traits. To this end, we used genome-wide association summary statistics for sociability and 31 activity and 64 connectivity DMN-related rs-fMRI traits (N=34,691-342,461). First, we examined global and local genetic correlations between sociability and the rs-fMRI traits. Second, to assess putatively causal relationships between the traits, we conducted bi-directional Mendelian randomisation (MR) analyses. Finally, we prioritised genes influencing both soci2024-01-01T00:00:00Z2024 May2026-04-08T06:04:09.856Z2026-04-07T22:50:58.112ZS-EPMC111422653882622010.1101/2024.05.24.24307883