{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao R"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS"],"pagination":["e0303446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142483"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(5)"],"pubmed_abstract":["<h4>Background</h4>Acute rejection (AR) after kidney transplantation is an important allograft complication. To reduce the risk of post-transplant AR, determination of kidney transplant donor-recipient mismatching focuses on blood type and human leukocyte antigens (HLA), while it remains unclear whether non-HLA genetic mismatching is related to post-transplant complications.<h4>Methods</h4>We carried out a genome-wide scan (HLA and non-HLA regions) on AR with a large kidney transplant cohort of 784 living donor-recipient pairs of European ancestry. An AR polygenic risk score (PRS) was constructed with the non-HLA single nucleotide polymorphisms (SNPs) filtered by independence (r2 < 0.2) and P-value (< 1×10-3) criteria. The PRS was validated in an independent cohort of 352 living donor-reci"],"journal":["PloS one"],"pubmed_title":["Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch."],"pmcid":["PMC11142483"],"funding_grant_id":["5U19-AI070119","5U01-AI058013","U19 AI070119","U01 AI058013"],"pubmed_authors":["Israni A","Schladt DP","Matas AJ","Guan W","Dorr C","Chen J","Jacobson PA","Cao R","Oetting WS"],"additional_accession":[]},"is_claimable":false,"name":"Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch.","description":"<h4>Background</h4>Acute rejection (AR) after kidney transplantation is an important allograft complication. To reduce the risk of post-transplant AR, determination of kidney transplant donor-recipient mismatching focuses on blood type and human leukocyte antigens (HLA), while it remains unclear whether non-HLA genetic mismatching is related to post-transplant complications.<h4>Methods</h4>We carried out a genome-wide scan (HLA and non-HLA regions) on AR with a large kidney transplant cohort of 784 living donor-recipient pairs of European ancestry. An AR polygenic risk score (PRS) was constructed with the non-HLA single nucleotide polymorphisms (SNPs) filtered by independence (r2 < 0.2) and P-value (< 1×10-3) criteria. The PRS was validated in an independent cohort of 352 living donor-reci","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-02T11:35:16.477Z","creation":"2025-08-14T03:05:42.45Z"},"accession":"S-EPMC11142483","cross_references":{"pubmed":["38820342"],"doi":["10.1371/journal.pone.0303446"]}}