{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["119(6)"],"submitter":["Leite G"],"funding":["Monica Lester Charitable Trust","Elias, Genevieve, and Georgianna Atol Charitable Trust"],"pubmed_abstract":["<h4>Introduction</h4>Gut microbiome changes are linked to obesity, but findings are based on stool data. In this article, we analyzed the duodenal microbiome and serum biomarkers in subjects with normal weight, overweight, and obesity.<h4>Methods</h4>Duodenal aspirates and serum samples were obtained from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation. Aspirate DNAs were analyzed by 16S rRNA and shotgun sequencing. Predicted microbial metabolic functions and serum levels of metabolic and inflammatory biomarkers were also assessed.<h4>Results</h4>Subjects with normal weight (N = 105), overweight (N = 67), and obesity (N = 42) were identified. Overweight-specific duodenal microbial features include lower relative abundance (RA) of Bifidobacterium sp"],"journal":["The American journal of gastroenterology"],"pagination":["1141-1153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142649"],"repository":["biostudies-literature"],"pubmed_title":["Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity."],"pmcid":["PMC11142649"],"pubmed_authors":["Parodi G","Morales W","Leite G","Rashid M","Rezaie A","Pimentel M","Hosseini A","Cohrs D","Weitsman S","Barlow GM","Mathur R"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity.","description":"<h4>Introduction</h4>Gut microbiome changes are linked to obesity, but findings are based on stool data. In this article, we analyzed the duodenal microbiome and serum biomarkers in subjects with normal weight, overweight, and obesity.<h4>Methods</h4>Duodenal aspirates and serum samples were obtained from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation. Aspirate DNAs were analyzed by 16S rRNA and shotgun sequencing. Predicted microbial metabolic functions and serum levels of metabolic and inflammatory biomarkers were also assessed.<h4>Results</h4>Subjects with normal weight (N = 105), overweight (N = 67), and obesity (N = 42) were identified. Overweight-specific duodenal microbial features include lower relative abundance (RA) of Bifidobacterium sp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-08T06:03:56.358Z","creation":"2026-06-08T03:14:24.107Z"},"accession":"S-EPMC11142649","cross_references":{"pubmed":["38578969"],"doi":["10.14309/ajg.0000000000002790"]}}