{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ban Z"],"funding":["the project of Sichuan Medical Association"],"pagination":["e0303593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(5)"],"pubmed_abstract":["<h4>Background</h4>Rheumatoid arthritis (RA) is a common inflammatory and autoimmune disease. Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) is a crucial and a rate-limiting enzyme responsible for deoxynucleotide triphosphate(dNTP) production. We have found a high expression level of RRM2 in patients with RA, but the molecular mechanism of its action remains unclear.<h4>Methods</h4>We analyzed the expression of hub genes in RA using GSE77298 datasets downloaded from Gene Expression Omnibus database. RRM2 and insulin-like growth factor-2 messenger ribonucleic acid (mRNA)-binding protein 3 (IGF2BP3) gene knockdown was achieved by infection with lentiviruses. The expression of RRM2, IGF2BP3, matrix metalloproteinase (MMP)-1, and MMP-9 were detected via western blotting assay. Cell viab"],"journal":["PloS one"],"pubmed_title":["IGF2BP3 regulates the expression of RRM2 and promotes the progression of rheumatoid arthritis via RRM2/Akt/MMP-9 pathway."],"pmcid":["PMC11142689"],"funding_grant_id":["No.2021SAT13, S21088"],"pubmed_authors":["Li Z","Ban Z","Xing S","Ye Y"],"additional_accession":[]},"is_claimable":false,"name":"IGF2BP3 regulates the expression of RRM2 and promotes the progression of rheumatoid arthritis via RRM2/Akt/MMP-9 pathway.","description":"<h4>Background</h4>Rheumatoid arthritis (RA) is a common inflammatory and autoimmune disease. Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) is a crucial and a rate-limiting enzyme responsible for deoxynucleotide triphosphate(dNTP) production. We have found a high expression level of RRM2 in patients with RA, but the molecular mechanism of its action remains unclear.<h4>Methods</h4>We analyzed the expression of hub genes in RA using GSE77298 datasets downloaded from Gene Expression Omnibus database. RRM2 and insulin-like growth factor-2 messenger ribonucleic acid (mRNA)-binding protein 3 (IGF2BP3) gene knockdown was achieved by infection with lentiviruses. The expression of RRM2, IGF2BP3, matrix metalloproteinase (MMP)-1, and MMP-9 were detected via western blotting assay. Cell viab","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-29T14:34:09.906Z","creation":"2026-04-07T15:16:11.697Z"},"accession":"S-EPMC11142689","cross_references":{"pubmed":["38820515"],"doi":["10.1371/journal.pone.0303593"]}}