{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barata P"],"funding":["NA","NCI NIH HHS"],"pagination":["e178915"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142736"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(11)"],"pubmed_abstract":["Molecular profiling of clear cell renal cell carcinoma (ccRCC) tumors of patients in a clinical trial has identified distinct transcriptomic signatures with predictive value, yet data in non-clear cell variants (nccRCC) are lacking. We examined the transcriptional profiles of RCC tumors representing key molecular pathways, from a multi-institutional, real-world patient cohort, including ccRCC and centrally reviewed nccRCC samples. ccRCC had increased angiogenesis signature scores compared with the heterogeneous group of nccRCC tumors, while cell cycle, fatty acid oxidation/AMPK signaling, and fatty acid synthesis/pentose phosphate signature scores were increased in one or more nccRCC subtypes. Among both ccRCC and nccRCC tumors, T effector scores statistically correlated with increased immune cell infiltration and were more commonly associated with immunotherapy-related markers (PD-L1+/TMBhi/MSIhi). In conclusion, this study provides evidence of differential gene transcriptional profiles among ccRCC versus nccRCC tumors, providing insights for optimizing personalized and histology-specific therapeutic strategies for patients with advanced RCC."],"journal":["The Journal of clinical investigation"],"pubmed_title":["Renal cell carcinoma histologic subtypes exhibit distinct transcriptional profiles."],"pmcid":["PMC11142736"],"funding_grant_id":["K08 CA273542","NA"],"pubmed_authors":["Geynisman DM","Hammers HJ","Dawson NA","Gulati S","Basu A","Heath EI","Bilen MA","Poorman KA","Ryan CJ","Zhang T","Nabhan C","Barata P","Gartrell BA","Wei S","Elliott A","Burgess E","McKay RR","Darabi S","Zibelman MR"],"additional_accession":[]},"is_claimable":false,"name":"Renal cell carcinoma histologic subtypes exhibit distinct transcriptional profiles.","description":"Molecular profiling of clear cell renal cell carcinoma (ccRCC) tumors of patients in a clinical trial has identified distinct transcriptomic signatures with predictive value, yet data in non-clear cell variants (nccRCC) are lacking. We examined the transcriptional profiles of RCC tumors representing key molecular pathways, from a multi-institutional, real-world patient cohort, including ccRCC and centrally reviewed nccRCC samples. ccRCC had increased angiogenesis signature scores compared with the heterogeneous group of nccRCC tumors, while cell cycle, fatty acid oxidation/AMPK signaling, and fatty acid synthesis/pentose phosphate signature scores were increased in one or more nccRCC subtypes. Among both ccRCC and nccRCC tumors, T effector scores statistically correlated with increased immune cell infiltration and were more commonly associated with immunotherapy-related markers (PD-L1+/TMBhi/MSIhi). In conclusion, this study provides evidence of differential gene transcriptional profiles among ccRCC versus nccRCC tumors, providing insights for optimizing personalized and histology-specific therapeutic strategies for patients with advanced RCC.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-29T14:07:03.484Z","creation":"2026-04-07T15:15:18.906Z"},"accession":"S-EPMC11142736","cross_references":{"pubmed":["38652565"],"doi":["10.1172/JCI178915"]}}