biostudies-literatureMoe ANIAID NIH HHSNational Heart, Lung, and Blood InstituteNHLBI NIH HHSMinesterio de Ciencia e Innovacion/Agencia Estatal de Investigacione175205https://www.ebi.ac.uk/biostudies/studies/S-EPMC11142740biostudies-literatureUnknown134(11)Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely understood. Using a murine model of GVHD, we demonstrate that type 2 cannabinoid receptor (CB2R) signaling plays a critical role in the pathophysiology of neuroinflammation. In these studies, we identify that CB2R expression on microglial cells induces an activated inflammatory phenotype that potentiateThe Journal of clinical investigationType 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease.PMC11142740R56 AI176611PID2019-108992RB-I00R01 AI148403R01 HL154579Romero JHillard CJMoore BMColonna MCui WZamora AESzabo ADrobyski WRMoe ASauber GYuan CYRayasam AShah RKDoherty AfalseType 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease.Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely understood. Using a murine model of GVHD, we demonstrate that type 2 cannabinoid receptor (CB2R) signaling plays a critical role in the pathophysiology of neuroinflammation. In these studies, we identify that CB2R expression on microglial cells induces an activated inflammatory phenotype that potentiate2024-01-01T00:00:00Z2024 Apr2026-04-29T14:04:20.475Z2026-04-07T15:14:57.434ZS-EPMC111427403866245310.1172/JCI175205