{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arribas V"],"funding":["German Research Foundation","panish Ministry of Science, Innovation and Universities","Fundació la Marato TV3","Spanish Ministry of Science, Innovation and Universities"],"pagination":["e177819"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11143933"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that regulates gene expression, and its malfunction in neurons has been causally associated with multiple neurodegenerative disorders. Although progress has been made in understanding the functions of TDP-43 in neurons, little is known about its roles in endothelial cells (ECs), angiogenesis, and vascular function. Using inducible EC-specific TDP-43-KO mice, we showed that TDP-43 is required for sprouting angiogenesis, vascular barrier integrity, and blood vessel stability. Postnatal EC-specific deletion of TDP-43 led to retinal hypovascularization due to defects in vessel sprouting associated with reduced EC proliferation and migration. In mature blood vessels, loss of TDP-43 disrupted the blood-brain barrier and triggered v"],"journal":["JCI insight"],"pubmed_title":["Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation."],"pmcid":["PMC11143933"],"funding_grant_id":["TRR359","PID2020-119315GB-I00","202327 10","PID2022-141840OB-I00","PID2021-124400OA-I00","PID2019-108902GB-I00","TRR332"],"pubmed_authors":["Onetti Y","Sperandio M","Martinez-Estrada OM","Schmid B","Merkel A","Ramiro-Pareta M","Montanez E","Villacampa P","Alberola M","Esteve-Codina A","Arribas V","Beck H"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation.","description":"TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that regulates gene expression, and its malfunction in neurons has been causally associated with multiple neurodegenerative disorders. Although progress has been made in understanding the functions of TDP-43 in neurons, little is known about its roles in endothelial cells (ECs), angiogenesis, and vascular function. Using inducible EC-specific TDP-43-KO mice, we showed that TDP-43 is required for sprouting angiogenesis, vascular barrier integrity, and blood vessel stability. Postnatal EC-specific deletion of TDP-43 led to retinal hypovascularization due to defects in vessel sprouting associated with reduced EC proliferation and migration. In mature blood vessels, loss of TDP-43 disrupted the blood-brain barrier and triggered v","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-02T08:32:45.078Z","creation":"2026-04-16T03:11:31.76Z"},"accession":"S-EPMC11143933","cross_references":{"pubmed":["38300714"],"doi":["10.1172/jci.insight.177819"]}}