{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chung HK"],"funding":["NIDDK NIH HHS","NIH"],"pagination":["e169716"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11143936"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["Circular RNAs (circRNAs) are highly expressed in the mammalian intestinal epithelium, but their functions remain largely unknown. Here, we identified the circRNA Cdr1as as a repressor of intestinal epithelial regeneration and defense. Cdr1as levels increased in mouse intestinal mucosa after colitis and septic stress, as well as in human intestinal mucosa from patients with inflammatory bowel disease and sepsis. Ablation of the Cdr1as locus from the mouse genome enhanced renewal of the intestinal mucosa, promoted injury-induced epithelial regeneration, and protected the mucosa against colitis. We found approximately 40 microRNAs, including miR-195, differentially expressed between intestinal mucosa of Cdr1as-knockout (Cdr1as-/-) versus littermate mice. Increasing the levels of Cdr1as inhibi"],"journal":["JCI insight"],"pubmed_title":["Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium."],"pmcid":["PMC11143936"],"funding_grant_id":["DK57819,DK61972,DK68491","R01 DK057819","R01 DK068491","R01 DK061972"],"pubmed_authors":["Turner DJ","Chung HK","Rao JN","Xiao L","Chen J","Gorospe M","Han N","Cairns CM","Kozar R","Wang JY","Yao V","Raufman B"],"additional_accession":[]},"is_claimable":false,"name":"Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium.","description":"Circular RNAs (circRNAs) are highly expressed in the mammalian intestinal epithelium, but their functions remain largely unknown. Here, we identified the circRNA Cdr1as as a repressor of intestinal epithelial regeneration and defense. Cdr1as levels increased in mouse intestinal mucosa after colitis and septic stress, as well as in human intestinal mucosa from patients with inflammatory bowel disease and sepsis. Ablation of the Cdr1as locus from the mouse genome enhanced renewal of the intestinal mucosa, promoted injury-induced epithelial regeneration, and protected the mucosa against colitis. We found approximately 40 microRNAs, including miR-195, differentially expressed between intestinal mucosa of Cdr1as-knockout (Cdr1as-/-) versus littermate mice. Increasing the levels of Cdr1as inhibi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-03T06:54:11.192Z","creation":"2026-04-25T03:22:33.137Z"},"accession":"S-EPMC11143936","cross_references":{"pubmed":["38227372"],"doi":["10.1172/jci.insight.169716"]}}