{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blake JM"],"funding":["NIH HHS"],"pagination":["3099-3106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11144447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(12)"],"pubmed_abstract":["Both genetic and non-genetic factors contribute to individual variation in the immune response to vaccination. Understanding how genetic background influences variation in both magnitude and persistence of vaccine-induced immunity is vital for improving vaccine development and identifying possible causes of vaccine failure. Dogs provide a relevant biomedical model for investigating mammalian vaccine genetics; canine breed structure and long linkage disequilibrium simplify genetic studies in this species compared to humans. The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens, and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a "],"journal":["Vaccine"],"pubmed_title":["Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study."],"pmcid":["PMC11144447"],"funding_grant_id":["K01 OD027051","OT2 OD002751"],"pubmed_authors":["Blake JM","Thompson J","Ekenstedt KJ","HogenEsch H"],"additional_accession":[]},"is_claimable":false,"name":"Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study.","description":"Both genetic and non-genetic factors contribute to individual variation in the immune response to vaccination. Understanding how genetic background influences variation in both magnitude and persistence of vaccine-induced immunity is vital for improving vaccine development and identifying possible causes of vaccine failure. Dogs provide a relevant biomedical model for investigating mammalian vaccine genetics; canine breed structure and long linkage disequilibrium simplify genetic studies in this species compared to humans. The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens, and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-06-27T03:05:43.931Z","creation":"2025-06-27T03:05:43.931Z"},"accession":"S-EPMC11144447","cross_references":{"pubmed":["38604911"],"doi":["10.1016/j.vaccine.2024.03.076"]}}