biostudies-literatureUnknown6(3)Thanh Vu HT<h4>Objective</h4>To identify the efficacy and tolerability of Proteoglycan F in patients with primary knee OA.<i>Design</i>: A 24-week randomized, placebo-controlled, double-blind clinical trial with two arms: (1) Proteoglycan F (received 10 ​mg proteoglycan daily, for 24 weeks) and (2) control group (received placebo). Knee symptoms and joint cartilage status (evaluated by ultrasound and MRI of knee joints), quality of life, serum cytokine levels <b>(</b>IL-1β and TNF-α), and safety evaluation were measured before, during, and after the treatment.<h4>Results</h4>After 24-week treatment, pain reduction (in the KOOS pain score) of at least 20% and at least 50% (NRS scale) compared to baseline in the PGF group was significantly higher than those in the control group. The PGF group had greatOsteoarthritis and cartilage open100483https://www.ebi.ac.uk/biostudies/studies/S-EPMC11145540biostudies-literatureThe efficacy and tolerability of proteoglycan F in the treatment of knee osteoarthritis: A prospective, randomized, double-blind controlled trial.PMC11145540Thu Nguyen HTNguyen ATIddamalgoda AHoai Nguyen TTLe TDLa HTNguyen ALThanh Vu HTNghiem TNTakahashi TPham TIto KNguyen TXThu Vu HTNguyen TNNguyen LTHBui QTTfalseThe efficacy and tolerability of proteoglycan F in the treatment of knee osteoarthritis: A prospective, randomized, double-blind controlled trial.<h4>Objective</h4>To identify the efficacy and tolerability of Proteoglycan F in patients with primary knee OA.<i>Design</i>: A 24-week randomized, placebo-controlled, double-blind clinical trial with two arms: (1) Proteoglycan F (received 10 ​mg proteoglycan daily, for 24 weeks) and (2) control group (received placebo). Knee symptoms and joint cartilage status (evaluated by ultrasound and MRI of knee joints), quality of life, serum cytokine levels <b>(</b>IL-1β and TNF-α), and safety evaluation were measured before, during, and after the treatment.<h4>Results</h4>After 24-week treatment, pain reduction (in the KOOS pain score) of at least 20% and at least 50% (NRS scale) compared to baseline in the PGF group was significantly higher than those in the control group. The PGF group had great2024-01-01T00:00:00Z2024 Sep2026-07-15T07:50:26.401Z2026-07-01T03:08:04.712ZS-EPMC111455403883205110.1016/j.ocarto.2024.100483