biostudies-literatureSanjayRural Development AdministrationCooperative Research Program for Agriculture Science and Technology Development103197https://www.ebi.ac.uk/biostudies/studies/S-EPMC11145555biostudies-literatureUnknown73Astrocytes are the major glial cells in the human brain and provide crucial metabolic and trophic support to neurons. The amyloid-β peptide (Aβ) alter the morphological and functional properties of astrocytes and induce inflammation and calcium dysregulation, contributing to Alzheimer's disease (AD) pathology. Recent studies highlight the role of Toll-like receptor (TLR) 4/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in inflammation. Reactive oxygen species (ROS) generated due to Aβ, induce apoptosis in the brain cells worsening AD progression. Astrocytic cell surface receptors, such as purinergic receptors (P2Y1 and P2Y2), metabotropic glutamate receptor (mGLUR)5, α7 nicotinic acetylcholine receptor (α7nAChR), and N-methyl-d-aspartate receptors (NMDARs)Redox biologyNobiletin regulates intracellular Ca²⁺ levels via IP₃R and ameliorates neuroinflammation in Aβ42-induced astrocytes.PMC11145555RS-2022-RD010230Sood RKang SUJaiswal VPark MLee HJSanjayfalseNobiletin regulates intracellular Ca²⁺ levels via IP₃R and ameliorates neuroinflammation in Aβ42-induced astrocytes.Astrocytes are the major glial cells in the human brain and provide crucial metabolic and trophic support to neurons. The amyloid-β peptide (Aβ) alter the morphological and functional properties of astrocytes and induce inflammation and calcium dysregulation, contributing to Alzheimer's disease (AD) pathology. Recent studies highlight the role of Toll-like receptor (TLR) 4/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in inflammation. Reactive oxygen species (ROS) generated due to Aβ, induce apoptosis in the brain cells worsening AD progression. Astrocytic cell surface receptors, such as purinergic receptors (P2Y1 and P2Y2), metabotropic glutamate receptor (mGLUR)5, α7 nicotinic acetylcholine receptor (α7nAChR), and N-methyl-d-aspartate receptors (NMDARs)2024-01-01T00:00:00Z2024 Jul2026-06-01T05:28:38.217Z2026-04-08T09:40:31.413ZS-EPMC111455553878173010.1016/j.redox.2024.103197