{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Monzon-Casanova E"],"funding":["Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["2266-2273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11146436"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(9)"],"pubmed_abstract":["The maturation of immature B cells and the survival of mature B cells is stringently controlled to maintain a diverse repertoire of antibody specificities while avoiding self-reactivity. At the molecular level this is regulated by signaling from membrane Ig and the BAFF-receptor that sustain a pro-survival program of gene expression. Whether and how posttranscriptional mechanisms contribute to B cell maturation and survival remains poorly understood. Here, we show that the polypyrimidine tract binding proteins (PTBP) PTBP1 and PTBP3 bind to a large and overlapping set of transcripts in B cells. Both PTBP1 and PTBP3 bind to introns and exons where they are predicted to regulate alternative splicing. Moreover, they also show high-density of binding to 3' untranslated regions suggesting they "],"journal":["European journal of immunology"],"pubmed_title":["Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice."],"pmcid":["PMC11146436"],"funding_grant_id":["BBS/E/B/000C0407","BBS/E/B/000C0428","200823/Z/16/Z","BBS/E/B/000C0427","BB/P01898X/1","BB/J001457/1"],"pubmed_authors":["Smith CWJ","Monzon-Casanova E","Turner M","Bates KJ"],"additional_accession":[]},"is_claimable":false,"name":"Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice.","description":"The maturation of immature B cells and the survival of mature B cells is stringently controlled to maintain a diverse repertoire of antibody specificities while avoiding self-reactivity. At the molecular level this is regulated by signaling from membrane Ig and the BAFF-receptor that sustain a pro-survival program of gene expression. Whether and how posttranscriptional mechanisms contribute to B cell maturation and survival remains poorly understood. Here, we show that the polypyrimidine tract binding proteins (PTBP) PTBP1 and PTBP3 bind to a large and overlapping set of transcripts in B cells. Both PTBP1 and PTBP3 bind to introns and exons where they are predicted to regulate alternative splicing. Moreover, they also show high-density of binding to 3' untranslated regions suggesting they ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-06-02T06:16:34.224Z","creation":"2026-04-15T03:15:07.101Z"},"accession":"S-EPMC11146436","cross_references":{"pubmed":["34214192"],"doi":["10.1002/eji.202149257"]}}