{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Todtenhaupt P"],"funding":["Merck | Merck Healthcare KGaA","Hartstichting"],"pagination":["e202302543"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11147950"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(8)"],"pubmed_abstract":["The human umbilical cord (hUC) is the lifeline that connects the fetus to the mother. Hypercoiling of the hUC is associated with pre- and perinatal morbidity and mortality. We investigated the origin of hUC hypercoiling using state-of-the-art imaging and omics approaches. Macroscopic inspection of the hUC revealed the helices to originate from the arteries rather than other components of the hUC. Digital reconstruction of the hUC arteries showed the dynamic alignment of two layers of muscle fibers in the tunica media aligning in opposing directions. We observed that genetically identical twins can be discordant for hUC coiling, excluding genetic, many environmental, and parental origins of hUC coiling. Comparing the transcriptomic and DNA methylation profile of the hUC arteries of four twi"],"journal":["Life science alliance"],"pubmed_title":["Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins."],"pmcid":["PMC11147950"],"funding_grant_id":["NaN","2017T075"],"pubmed_authors":["Roest AA","Lopriore E","Voortman LM","Todtenhaupt P","Kuipers TB","Dijkstra KL","Jonkman TH","Heijmans BT","Verweij ET","Groene SG","van der Meeren LE","Spekman JA","van Pel M","Franken LA","Haak MC"],"additional_accession":[]},"is_claimable":false,"name":"Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins.","description":"The human umbilical cord (hUC) is the lifeline that connects the fetus to the mother. Hypercoiling of the hUC is associated with pre- and perinatal morbidity and mortality. We investigated the origin of hUC hypercoiling using state-of-the-art imaging and omics approaches. Macroscopic inspection of the hUC revealed the helices to originate from the arteries rather than other components of the hUC. Digital reconstruction of the hUC arteries showed the dynamic alignment of two layers of muscle fibers in the tunica media aligning in opposing directions. We observed that genetically identical twins can be discordant for hUC coiling, excluding genetic, many environmental, and parental origins of hUC coiling. Comparing the transcriptomic and DNA methylation profile of the hUC arteries of four twi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-07-15T04:35:25.794Z","creation":"2026-06-30T03:07:08.426Z"},"accession":"S-EPMC11147950","cross_references":{"pubmed":["38830769"],"doi":["10.26508/lsa.202302543"]}}