{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Montenegro J"],"funding":["Almased Wellness-GmbH","Innovation John R Evans Leaders Fund","Mitacs Accelerate International"],"pagination":["e070027"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11148686"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(9)"],"pubmed_abstract":["<h4>Introduction</h4>Excess body weight is associated with a state of low-grade chronic inflammation and alterations of the gut microbiome. Powdered meal replacements (PMR) have been shown to be an effective strategy for weight management; however, their effect on inflammation and the gut microbiome remains unclear. The aim of this 12-week randomised control clinical trial is to investigate the effects of PMR consumption, here given as a soy-yoghurt-honey formula, on inflammation, gut microbiome and overall metabolism in individuals with excessive body weight.<h4>Methods and analysis</h4>Healthy adults with excess body weight (n=88) are being recruited and randomly assigned to one of the following groups: (1) Control group (CON): maintaining usual diet for 12 weeks, or (2) PMR group: repla"],"journal":["BMJ open"],"pubmed_title":["Impact of a Powdered Meal Replacement on Metabolism and Gut Microbiota (PREMIUM) in individuals with excessive body weight: a study protocol for a randomised controlled trial."],"pmcid":["PMC11148686"],"funding_grant_id":["Project # 34115","RES0055192","RES0035331"],"pubmed_authors":["L P Oliveira C","Sharma AM","Walter J","Richard C","Ghosh S","Armet AM","Mereu L","Cominetti C","Montenegro J","Berg A","Cani PD","Prado CM","Nguyen NK"],"additional_accession":[]},"is_claimable":false,"name":"Impact of a Powdered Meal Replacement on Metabolism and Gut Microbiota (PREMIUM) in individuals with excessive body weight: a study protocol for a randomised controlled trial.","description":"<h4>Introduction</h4>Excess body weight is associated with a state of low-grade chronic inflammation and alterations of the gut microbiome. Powdered meal replacements (PMR) have been shown to be an effective strategy for weight management; however, their effect on inflammation and the gut microbiome remains unclear. The aim of this 12-week randomised control clinical trial is to investigate the effects of PMR consumption, here given as a soy-yoghurt-honey formula, on inflammation, gut microbiome and overall metabolism in individuals with excessive body weight.<h4>Methods and analysis</h4>Healthy adults with excess body weight (n=88) are being recruited and randomly assigned to one of the following groups: (1) Control group (CON): maintaining usual diet for 12 weeks, or (2) PMR group: repla","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-02T19:23:18.355Z","creation":"2026-04-19T03:13:44.202Z"},"accession":"S-EPMC11148686","cross_references":{"pubmed":["37709337"],"doi":["10.1136/bmjopen-2022-070027"]}}