biostudies-literatureMontenegro JAlmased Wellness-GmbHInnovation John R Evans Leaders FundMitacs Accelerate Internationale070027https://www.ebi.ac.uk/biostudies/studies/S-EPMC11148686biostudies-literatureUnknown13(9)<h4>Introduction</h4>Excess body weight is associated with a state of low-grade chronic inflammation and alterations of the gut microbiome. Powdered meal replacements (PMR) have been shown to be an effective strategy for weight management; however, their effect on inflammation and the gut microbiome remains unclear. The aim of this 12-week randomised control clinical trial is to investigate the effects of PMR consumption, here given as a soy-yoghurt-honey formula, on inflammation, gut microbiome and overall metabolism in individuals with excessive body weight.<h4>Methods and analysis</h4>Healthy adults with excess body weight (n=88) are being recruited and randomly assigned to one of the following groups: (1) Control group (CON): maintaining usual diet for 12 weeks, or (2) PMR group: replaBMJ openImpact of a Powdered Meal Replacement on Metabolism and Gut Microbiota (PREMIUM) in individuals with excessive body weight: a study protocol for a randomised controlled trial.PMC11148686Project # 34115RES0055192RES0035331L P Oliveira CSharma AMWalter JRichard CGhosh SArmet AMMereu LCominetti CMontenegro JBerg ACani PDPrado CMNguyen NKfalseImpact of a Powdered Meal Replacement on Metabolism and Gut Microbiota (PREMIUM) in individuals with excessive body weight: a study protocol for a randomised controlled trial.<h4>Introduction</h4>Excess body weight is associated with a state of low-grade chronic inflammation and alterations of the gut microbiome. Powdered meal replacements (PMR) have been shown to be an effective strategy for weight management; however, their effect on inflammation and the gut microbiome remains unclear. The aim of this 12-week randomised control clinical trial is to investigate the effects of PMR consumption, here given as a soy-yoghurt-honey formula, on inflammation, gut microbiome and overall metabolism in individuals with excessive body weight.<h4>Methods and analysis</h4>Healthy adults with excess body weight (n=88) are being recruited and randomly assigned to one of the following groups: (1) Control group (CON): maintaining usual diet for 12 weeks, or (2) PMR group: repla2023-01-01T00:00:00Z2023 Sep2026-06-02T19:23:18.355Z2026-04-19T03:13:44.202ZS-EPMC111486863770933710.1136/bmjopen-2022-070027