{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huggins AA"],"funding":["NICHD NIH HHS","NIBIB NIH HHS","NCATS NIH HHS","NIA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","RRD VA","U.S. Department of Defense (United States Department of Defense)","NINDS NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)","Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation)","U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)","NCRR NIH HHS","Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation)","HSRD VA","ZonMw","U.S. Department of Veterans Affairs (Department of Veterans Affairs)","CSRD VA","Deutsche Forschungsgemeinschaft (German Research Foundation)","United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP)","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","Department of Health | National Health and Medical Research Council (NHMRC)","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["611-623"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11153161"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(3)"],"pubmed_abstract":["Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associa"],"journal":["Molecular psychiatry"],"pubmed_title":["Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup."],"pmcid":["PMC11153161"],"funding_grant_id":["DA 1222/4-1","K01MH118467","UL1TR000454","R01 MH117601","R01MH111671","R01 MH119227","HD085850","M01 RR000039","R21MH112956","K01 MH118467","HD071982","IK2 CX001680","IK2 RX002922","K23MH090366","R01AG059874","R21MH102634","K23 MH090366","T32 MH018931","R01MH105535","I01 CX002097","I01 CX002096","K12 HD085850","R01 MH129832","MH101380","BK20221554","UL1 TR000454","R01 MH107382","1184403","W81XWH-08-2-0038","U54 EB020403","R01MH110483","R01 AG059874","R21 MH106998","I01 CX001135","1K2RX002922","R01MH107382","R01 AG064955","R01MH106574","R01 MH105355","P41 EB015922","R21 MH098212","U21A20364","R01 AG022381","R01MH119227","R01MH117601","I01RX000622","I01 CX001820","R01 MH043454","14848","I01 RX001880","I01 RX002174","I01 RX002173","R01MH096987","I01 RX002172","I01 RX002171","I01 RX002170","R01MH105355","K01 MH122774","P30 HD003352","K01MH118428","20ZDA079","I01 RX001774","I01 RX001135","IK2 RX000709","R01AG022381","R01 MH105535","1IK2RX000709","R01 MH096987","R61 NS120249","R56 AG058854","27040","WA 1539/8-2","R21MH098198","I01 HX003155","R01 MH111671","R21MH106998","SFB/TRR 58: C06, C07","K01MH122774","R01 MH113574","I01 RX003444","I01 RX003443","I01 CX001246","I01 RX003442","I01 RX002076","R61NS120249","R01 MH106574","R01 HD071982","R56 MH071537","K01 MH118428","W81XWH-10-1-0925","1IK2CX001680","R21 MH112956","R21 MH102634","40-00812-98-10041","W81XWH-12-2-0012","R01AG050595","K23 MH101380","31971020","MH098212","M01RR00039","P50","MH071537","I01 RX000622","R01 AG050595","R01 MH116147","R01 MH071537","R01 AG076838"],"pubmed_authors":["deRoon-Cassini TA","Nelson SM","Huggins AA","Olson EA","Abdallah CG","Baugh LA","Nitschke JB","Nawjin L","Bruce S","Zilcha-Mano S","Riha P","Walter H","Fitzgerald JM","Davidson RJ","Levy I","He X","Briggs M","O'Leary EN","Harpaz-Rotem I","Magnotta VA","Zhu Y","May G","Qi R","Kremen WS","van Zuiden M","Fercho KA","Ressler KJ","Daniels JK","Ross M","Blackford JU","van Rooij SJH","Salminen LE","Berg H","du Plessis S","Seedat S","Angstadt M","Rektor I","Liberzon I","Tomas CW","Stein DJ","Fani N","Suarez-Jimenez B","Zhu X","Kim Y","Herringa RJ","Hofmann D","Dennis EL","Davenport ND","Mueller SC","Franz CE","Baird CL","Tate DF","Forster GL","Disner SG","Jovanovic T","Wang L","Herzog JI","Baker JT","Xie H","Etkin A","Sun D","Cotton AS","Gordon EM","Laskowitz S","Olff M","Wang X","Olatunji BO","Lissek S","Koch SBJ","Li G","Manthey A","Hudson AR","El-Hage W","Haswell C","Neria Y","Thompson PM","Kerestes R","Larson CL","Morey R","Rosso IM","Kaufman ML","Lebois LAM","Cisler J","Wilde EA","Simons JS","Krystal JH","Stevens JS","Walker WC","Lu GM","Harding IH","Sierk A","Straube T","Hussain A","Fouda S","Simons RM","Jahanshad N","Veltman DJ","Lazarov A","King AP","Schmahl C","Frijling JL","Quide Y","Ipser J","Grupe DW","Lyons MJ","Sponheim SR","Maron-Katz A","Thomopoulos SI","van den Heuvel LL","Cifu DX"],"additional_accession":[]},"is_claimable":false,"name":"Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.","description":"Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associa","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-04-08T23:15:31.336Z","creation":"2026-04-07T13:18:08.704Z"},"accession":"S-EPMC11153161","cross_references":{"pubmed":["38195980"],"doi":["10.1038/s41380-023-02352-0"]}}