{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murgia M"],"funding":["Agenzia Spaziale Italiana","Agenzia Spaziale Italiana (Italian Space Agency)"],"pagination":["60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11153545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Skeletal muscle undergoes atrophy and loss of force during long space missions, when astronauts are persistently exposed to altered gravity and increased ionizing radiation. We previously carried out mass spectrometry-based proteomics from skeletal muscle biopsies of two astronauts, taken before and after a mission on the International Space Station. The experiments were part of an effort to find similarities between spaceflight and bed rest, a ground-based model of unloading, focused on proteins located at the costameres. We here extend the data analysis of the astronaut dataset and show compartment-resolved changes in the mitochondrial proteome, remodeling of the extracellular matrix and of the antioxidant response. The astronauts differed in their level of onboard physical exercise, whi"],"journal":["NPJ microgravity"],"pubmed_title":["Spaceflight on the ISS changed the skeletal muscle proteome of two astronauts."],"pmcid":["PMC11153545"],"funding_grant_id":["DC-VUM-2017-006"],"pubmed_authors":["Reggiani C","Schiaffino S","Murgia M","Narici MV","Rittweger J","Bottinelli R","Mann M"],"additional_accession":[]},"is_claimable":false,"name":"Spaceflight on the ISS changed the skeletal muscle proteome of two astronauts.","description":"Skeletal muscle undergoes atrophy and loss of force during long space missions, when astronauts are persistently exposed to altered gravity and increased ionizing radiation. We previously carried out mass spectrometry-based proteomics from skeletal muscle biopsies of two astronauts, taken before and after a mission on the International Space Station. The experiments were part of an effort to find similarities between spaceflight and bed rest, a ground-based model of unloading, focused on proteins located at the costameres. We here extend the data analysis of the astronaut dataset and show compartment-resolved changes in the mitochondrial proteome, remodeling of the extracellular matrix and of the antioxidant response. The astronauts differed in their level of onboard physical exercise, whi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-02T21:13:53.873Z","creation":"2026-05-29T03:06:43.178Z"},"accession":"S-EPMC11153545","cross_references":{"pubmed":["38839773"],"doi":["10.1038/s41526-024-00406-3"]}}