biostudies-literatureUnknownLester BMEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNIEHS NIH HHSNIMH NIH HHSNational Institute of Mental HealthNIH HHS<b>Aim:</b> The current work was designed to demonstrate the application of the exposome framework in examining associations between exposures and children's long-term neurodevelopmental and behavioral outcomes. <b>Methods:</b> Longitudinal data were collected from birth through age 6 from 402 preterm infants. Three statistical methods were utilized to demonstrate the exposome framework: exposome-wide association study, cumulative exposure and machine learning models, with and without epigenetic data. <b>Results:</b> Each statistical approach answered a distinct research question regarding the impact of exposures on longitudinal child outcomes. Findings highlight associations between exposures, epigenetics and executive function. <b>Conclusion:</b> Findings demonstrate how an exposome-baseEpigenomicshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11157992biostudies-literatureToward a more holistic approach to the study of exposures and child outcomes.PMC11157992K01MH129510R01 HD084515K01 MH129510R01 HD072267UH3 OD023347R01HD072267, R01HD084515, UH3OD023347U2C ES026555Marsit CJShuster CLEverson TMCamerota MLester BMfalseToward a more holistic approach to the study of exposures and child outcomes.<b>Aim:</b> The current work was designed to demonstrate the application of the exposome framework in examining associations between exposures and children's long-term neurodevelopmental and behavioral outcomes. <b>Methods:</b> Longitudinal data were collected from birth through age 6 from 402 preterm infants. Three statistical methods were utilized to demonstrate the exposome framework: exposome-wide association study, cumulative exposure and machine learning models, with and without epigenetic data. <b>Results:</b> Each statistical approach answered a distinct research question regarding the impact of exposures on longitudinal child outcomes. Findings highlight associations between exposures, epigenetics and executive function. <b>Conclusion:</b> Findings demonstrate how an exposome-base2024-01-01T00:00:00Z2024 Mar2026-07-15T07:38:10.013Z2026-07-01T03:07:38.212ZS-EPMC111579923848263910.2217/epi-2023-0424