{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bernhardt SM"],"funding":["NCI NIH HHS"],"pubmed_abstract":["Young women have increased risk of vitamin D deficiency, which may increase breast cancer incidence. Here, we assessed the anti-cancer efficacy of vitamin D in mouse models of young-onset breast cancer. In never-pregnant mice, vitamin D supplementation increased serum 25(OH)D and hepatic 1,25(OH)<sub>2</sub>D<sub>3</sub>, reduced tumor size, and associated with anti-tumor immunity. These anti-tumor effects were not replicated in a mouse model of postpartum breast cancer, where hepatic metabolism of vitamin D was suppressed post-wean, which resulted in deficient serum 25(OH)D and reduced hepatic 1,25(OH)<sub>2</sub>D<sub>3</sub>. Treatment with active 1,25(OH)<sub>2</sub>D<sub>3</sub> induced hypercalcemia exclusively in post-wean mice, highlighting metabolic imbalance post-wean. RNAseq rev"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.05.28.596304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11160686"],"repository":["biostudies-literature"],"pubmed_title":["Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model."],"pmcid":["PMC11160686"],"funding_grant_id":["P30 CA069533","R01 CA169175"],"pubmed_authors":["DeBarber AE","Xia Z","Schedin P","Ozaki MK","Fornetti J","Zhang Y","Bernhardt SM","Wilde De E","Bleyle LA","Betts C","Liberty AL"],"additional_accession":[]},"is_claimable":false,"name":"Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model.","description":"Young women have increased risk of vitamin D deficiency, which may increase breast cancer incidence. Here, we assessed the anti-cancer efficacy of vitamin D in mouse models of young-onset breast cancer. In never-pregnant mice, vitamin D supplementation increased serum 25(OH)D and hepatic 1,25(OH)<sub>2</sub>D<sub>3</sub>, reduced tumor size, and associated with anti-tumor immunity. These anti-tumor effects were not replicated in a mouse model of postpartum breast cancer, where hepatic metabolism of vitamin D was suppressed post-wean, which resulted in deficient serum 25(OH)D and reduced hepatic 1,25(OH)<sub>2</sub>D<sub>3</sub>. Treatment with active 1,25(OH)<sub>2</sub>D<sub>3</sub> induced hypercalcemia exclusively in post-wean mice, highlighting metabolic imbalance post-wean. RNAseq rev","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-07-05T03:17:04.223Z","creation":"2026-07-05T03:12:23.597Z"},"accession":"S-EPMC11160686","cross_references":{"pubmed":["38854129"],"doi":["10.1101/2024.05.28.596304"]}}