biostudies-literatureGuintivano JEuropean Research CouncilMedical Research CouncilNIMH NIH HHSWellcome Trust884-895https://www.ebi.ac.uk/biostudies/studies/S-EPMC11163373biostudies-literatureUnknown180(12)<h4>Objective</h4>Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.<h4>Method</h4>Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS finThe American journal of psychiatryMeta-Analyses of Genome-Wide Association Studies for Postpartum Depression.PMC11163373K01 MH116413R01 MH124839216767/Z/19/ZR01 MH125938R56 MH120736R01 MH118223K01 MH120352P50 MH077928R21 MH126358220857/Z/20/ZU01 MH109532101042183R01 MH124871802998K08 MH127413P50 MH068036U01 MH109528MR/L010305/1R01 MH123724R01 MH124873Tesli MStowe ZNPardinas AFHavdahl AMartin NGRobertson Blackmore ELu YDubertret CTaylor VChoi KWAnney RJLWray NSmoller JWFrey BNGuintivano JMullaert JXiong YByrne EMAndreassen OASealock JMKunovac Kallak TMægbæk MLOberlander THubbard LCorfield ECRaffield LMGordon-Smith KSkalkidou AZar HJYao STebeka SVan Lieshout RJSaquib NDi Florio AGloaguen EWestlye LTRamoz NPeterson RELi YVigod SNMajor Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumBigdeli TBJones IRubinow DDavis LKDennis CLKrohn HAberg KASullivan PWhiteman DCAdams MJNyegaard MReichborn-Kjennerud TWalker AMcIntosh AMWerge TMeltzer-Brody SShadyab AHFeng YAKoen NYang JMKMunk-Olsen TKennedy JLSallis HMWatson HJViktorin AMilgrom JPerry ACampbell MLHucks DBauer AEStein DJOlsen CMCampbell AGrigoriadis SKiewa JMihaescu RJones LAvan den Oord EJCGfalseMeta-Analyses of Genome-Wide Association Studies for Postpartum Depression.<h4>Objective</h4>Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.<h4>Method</h4>Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS fin2023-01-01T00:00:00Z2023 Dec2026-06-02T10:40:37.447Z2025-04-04T01:23:53.073ZS-EPMC111633733784930410.1176/appi.ajp.20230053