{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(10)"],"submitter":["Guo R"],"pubmed_abstract":["Numerous studies have investigated the role of <i>collagen type 1 α1</i> (<i>COL1A1)</i> polymorphisms in musculoskeletal soft tissue injuries (MSTIs), yielding conflicting results. This study was designed to synthesize existing evidence and clarify the relationship between <i>COL1A1</i> polymorphisms and MSTI susceptibility. We conducted a comprehensive literature search using PubMed, Cochrane Library, Web of Science, EMBASE, and Wanfang databases. Associations were assessed using odds ratios (ORs) with 95% confidence intervals (95% CIs) across five genetic models. Subgroup analyses were performed based on ethnicity and injury type. Additionally, trial sequential analysis (TSA) was utilized to assess information size and statistical power. We analyzed a total of 16 articles from 358 retri"],"journal":["Aging"],"pagination":["8866-8879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11164502"],"repository":["biostudies-literature"],"pubmed_title":["Associations of <i>collagen type 1 α1</i> gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis with trial sequential analysis."],"pmcid":["PMC11164502"],"pubmed_authors":["Aizezi A","Shaxika N","Feng X","Wang H","Guo R","Wang Z","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Associations of <i>collagen type 1 α1</i> gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis with trial sequential analysis.","description":"Numerous studies have investigated the role of <i>collagen type 1 α1</i> (<i>COL1A1)</i> polymorphisms in musculoskeletal soft tissue injuries (MSTIs), yielding conflicting results. This study was designed to synthesize existing evidence and clarify the relationship between <i>COL1A1</i> polymorphisms and MSTI susceptibility. We conducted a comprehensive literature search using PubMed, Cochrane Library, Web of Science, EMBASE, and Wanfang databases. Associations were assessed using odds ratios (ORs) with 95% confidence intervals (95% CIs) across five genetic models. Subgroup analyses were performed based on ethnicity and injury type. Additionally, trial sequential analysis (TSA) was utilized to assess information size and statistical power. We analyzed a total of 16 articles from 358 retri","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-29T16:29:47.451Z","creation":"2026-04-08T05:25:23.983Z"},"accession":"S-EPMC11164502","cross_references":{"pubmed":["38787354"],"doi":["10.18632/aging.205846"]}}