biostudies-literatureUnknown16(10)Guo RNumerous studies have investigated the role of <i>collagen type 1 α1</i> (<i>COL1A1)</i> polymorphisms in musculoskeletal soft tissue injuries (MSTIs), yielding conflicting results. This study was designed to synthesize existing evidence and clarify the relationship between <i>COL1A1</i> polymorphisms and MSTI susceptibility. We conducted a comprehensive literature search using PubMed, Cochrane Library, Web of Science, EMBASE, and Wanfang databases. Associations were assessed using odds ratios (ORs) with 95% confidence intervals (95% CIs) across five genetic models. Subgroup analyses were performed based on ethnicity and injury type. Additionally, trial sequential analysis (TSA) was utilized to assess information size and statistical power. We analyzed a total of 16 articles from 358 retriAging8866-8879https://www.ebi.ac.uk/biostudies/studies/S-EPMC11164502biostudies-literatureAssociations of <i>collagen type 1 α1</i> gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis with trial sequential analysis.PMC11164502Aizezi AShaxika NFeng XWang HGuo RWang ZGao SfalseAssociations of <i>collagen type 1 α1</i> gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis with trial sequential analysis.Numerous studies have investigated the role of <i>collagen type 1 α1</i> (<i>COL1A1)</i> polymorphisms in musculoskeletal soft tissue injuries (MSTIs), yielding conflicting results. This study was designed to synthesize existing evidence and clarify the relationship between <i>COL1A1</i> polymorphisms and MSTI susceptibility. We conducted a comprehensive literature search using PubMed, Cochrane Library, Web of Science, EMBASE, and Wanfang databases. Associations were assessed using odds ratios (ORs) with 95% confidence intervals (95% CIs) across five genetic models. Subgroup analyses were performed based on ethnicity and injury type. Additionally, trial sequential analysis (TSA) was utilized to assess information size and statistical power. We analyzed a total of 16 articles from 358 retri2024-01-01T00:00:00Z2024 May2026-05-29T16:29:47.451Z2026-04-08T05:25:23.983ZS-EPMC111645023878735410.18632/aging.205846