{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sharma B"],"funding":["NIA NIH HHS","NINDS NIH HHS"],"pagination":["2698-2707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11168514"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(12)"],"pubmed_abstract":["JOURNAL/nrgr/04.03/01300535-202412000-00026/figure1/v/2024-04-08T165401Z/r/image-tiff Gamma-aminobutyric acid (GABA)ergic neurons, the most abundant inhibitory neurons in the human brain, have been found to be reduced in many neurological disorders, including Alzheimer's disease and Alzheimer's disease-related dementia. Our previous study identified the upregulation of microRNA-502-3p (miR-502-3p) and downregulation of GABA type A receptor subunit α-1 in Alzheimer's disease synapses. This study investigated a new molecular relationship between miR-502-3p and GABAergic synapse function. In vitro studies were performed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and antagomiRs. In silico analysis identified multiple binding sites of miR-502-3p at GABA type A re"],"journal":["Neural regeneration research"],"pubmed_title":["MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons."],"pmcid":["PMC11168514"],"funding_grant_id":["R00 AG065645","K99 AG065645","R01 NS115834"],"pubmed_authors":["Sharma B","Rodriguez S","Torres MM","Gangwani L","Kumar S"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons.","description":"JOURNAL/nrgr/04.03/01300535-202412000-00026/figure1/v/2024-04-08T165401Z/r/image-tiff Gamma-aminobutyric acid (GABA)ergic neurons, the most abundant inhibitory neurons in the human brain, have been found to be reduced in many neurological disorders, including Alzheimer's disease and Alzheimer's disease-related dementia. Our previous study identified the upregulation of microRNA-502-3p (miR-502-3p) and downregulation of GABA type A receptor subunit α-1 in Alzheimer's disease synapses. This study investigated a new molecular relationship between miR-502-3p and GABAergic synapse function. In vitro studies were performed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and antagomiRs. In silico analysis identified multiple binding sites of miR-502-3p at GABA type A re","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-07-04T03:14:04.703Z","creation":"2026-07-04T03:11:00.697Z"},"accession":"S-EPMC11168514","cross_references":{"pubmed":["38595288"],"doi":["10.4103/NRR.NRR-D-23-01064"]}}