{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adams JL"],"funding":["Biogen, Inc. Cambridge, MA Critical Path Institute, Tucson, AZ","Takeda Pharmaceuticals U.S.A.","NCATS NIH HHS","Takeda Pharmaceutical Company Limited | Takeda Oncology"],"pagination":["112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11169239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Digital measures may provide objective, sensitive, real-world measures of disease progression in Parkinson's disease (PD). However, multicenter longitudinal assessments of such measures are few. We recently demonstrated that baseline assessments of gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, and research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD and 50 age-matched controls. Here, we evaluated the longitudinal change in these assessments over 12 months in a multicenter observational study using a generalized additive model, which permitted flexible modeling of at-home data. All measurements were included until participants started medications for PD. Over one year, individuals with early P"],"journal":["NPJ Parkinson's disease"],"pubmed_title":["Using a smartwatch and smartphone to assess early Parkinson's disease in the WATCH-PD study over 12 months."],"pmcid":["PMC11169239"],"funding_grant_id":["UL1 TR002369"],"pubmed_authors":["Best A","Stephenson D","Williams K","Khachadourian V","Tracey B","Waddell E","Kilbane C","Spindler M","Gong Y","Barrett MJ","Cosman J","Volfson D","Wakeman K","Mari Z","Soto J","Latzman RD","Kostrzebski MA","Tarolli C","Simuni T","Wyant KJ","Muller MLTM","Kangarloo T","Dumitrescu L","Wahedi M","Gunzler SA","Auinger P","Shprecher D","Espay AJ","Adams JL","Pohlson Y","Jensen-Roberts S","Parkinson Study Group Watch-PD Study Investigators and Collaborators","Poon C","Feigin A","Hogarth P","Feuerstein J","Dorsey ER","Tanner NLC","Anderson D","Edgerton J","Wilmot P","Chou KL","Botting E","Yilmaz E"],"additional_accession":[]},"is_claimable":false,"name":"Using a smartwatch and smartphone to assess early Parkinson's disease in the WATCH-PD study over 12 months.","description":"Digital measures may provide objective, sensitive, real-world measures of disease progression in Parkinson's disease (PD). However, multicenter longitudinal assessments of such measures are few. We recently demonstrated that baseline assessments of gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, and research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD and 50 age-matched controls. Here, we evaluated the longitudinal change in these assessments over 12 months in a multicenter observational study using a generalized additive model, which permitted flexible modeling of at-home data. All measurements were included until participants started medications for PD. Over one year, individuals with early P","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-07-15T05:55:34.108Z","creation":"2026-06-30T03:16:20.812Z"},"accession":"S-EPMC11169239","cross_references":{"pubmed":["38866793"],"doi":["10.1038/s41531-024-00721-2"]}}