{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["332(8)"],"submitter":["Abdul-Aziz MH"],"pubmed_abstract":["<h4>Importance</h4>There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock.<h4>Objective</h4>To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions.<h4>Data sources</h4>The primary search was conducted with MEDLINE (via PubMed), CINAHL, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov from inception to May 2, 2024.<h4>Study selection</h4>Randomized clinical trials comparing prolonged (continuous or extended) and intermittent infusions of β-lactam antibiotics in critically ill adults with sepsis or sep"],"journal":["JAMA"],"pagination":["638-648"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11170459"],"repository":["biostudies-literature"],"pubmed_title":["Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis."],"pmcid":["PMC11170459"],"pubmed_authors":["Delaney A","De Waele JJ","Dulhunty JM","Sjovall F","Cotta MO","Liu X","Rajbhandari D","Di Tanna GL","Omar S","Devaux A","Khan AB","Novy E","Lipman J","Monti G","Brett SJ","Hammond NE","Hasan MS","Zangrillo A","Elkady H","Roger C","Zaghi I","Abdul-Aziz MH","Myburgh J","Eriksson L","Roberts JA"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.","description":"<h4>Importance</h4>There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock.<h4>Objective</h4>To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions.<h4>Data sources</h4>The primary search was conducted with MEDLINE (via PubMed), CINAHL, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov from inception to May 2, 2024.<h4>Study selection</h4>Randomized clinical trials comparing prolonged (continuous or extended) and intermittent infusions of β-lactam antibiotics in critically ill adults with sepsis or sep","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-06T17:38:07.059Z","creation":"2025-04-06T15:07:48.528Z"},"accession":"S-EPMC11170459","cross_references":{"pubmed":["38864162"],"doi":["10.1001/jama.2024.9803"]}}