biostudies-literatureUnknown332(8)Abdul-Aziz MH<h4>Importance</h4>There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock.<h4>Objective</h4>To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions.<h4>Data sources</h4>The primary search was conducted with MEDLINE (via PubMed), CINAHL, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov from inception to May 2, 2024.<h4>Study selection</h4>Randomized clinical trials comparing prolonged (continuous or extended) and intermittent infusions of β-lactam antibiotics in critically ill adults with sepsis or sepJAMA638-648https://www.ebi.ac.uk/biostudies/studies/S-EPMC11170459biostudies-literatureProlonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.PMC11170459Delaney ADe Waele JJDulhunty JMSjovall FCotta MOLiu XRajbhandari DDi Tanna GLOmar SDevaux AKhan ABNovy ELipman JMonti GBrett SJHammond NEHasan MSZangrillo AElkady HRoger CZaghi IAbdul-Aziz MHMyburgh JEriksson LRoberts JAfalseProlonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.<h4>Importance</h4>There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock.<h4>Objective</h4>To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions.<h4>Data sources</h4>The primary search was conducted with MEDLINE (via PubMed), CINAHL, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov from inception to May 2, 2024.<h4>Study selection</h4>Randomized clinical trials comparing prolonged (continuous or extended) and intermittent infusions of β-lactam antibiotics in critically ill adults with sepsis or sep2024-01-01T00:00:00Z2024 Aug2026-06-06T17:38:07.059Z2025-04-06T15:07:48.528ZS-EPMC111704593886416210.1001/jama.2024.9803