{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aggarwal NR"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","University of Minnesota","National Cancer Institute","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["1490-1503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11175705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(6)"],"pubmed_abstract":["<h4>Background</h4>Persistent mortality in adults hospitalized due to acute COVID-19 justifies pursuit of disease mechanisms and potential therapies. The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) trials.<h4>Methods</h4>A secondary analysis of 2625 adults hospitalized for acute SARS-CoV-2 infection randomized to 1 of 5 antiviral products or matched placebo in 114 centers on 4 continents. Uniform, site-level collection of participant baseline clinical variables was performed. Research laboratories assayed baseline upper respiratory swabs for SARS-CoV-2 viral RNA and plasma for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleocapsid antigen (viral Ag), and interleukin"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19."],"pmcid":["PMC11175705"],"funding_grant_id":["U01 HL088942","U01-AI136780","75N91019D00024","OT2 HL156812","75N91020F00039","1OT2HL156812","UM1 HL088925","U01 AI136780"],"pubmed_authors":["Estrada L","Whitacre H","Parmar MKB","Fresnedo M","Isip TKK","Lane K","West E","Mistry SS","Chang CC","Sanchez MDL","Pastor E","Pillai A","Prekker M","Heysu RG","Stottlemyer A","Thornton K","Santana J","Broussard S","Frary S","Barros A","Selvamuthu P","McKaig B","Cesarini R","Horcajada JP","Sierra MP","Smith DM","Sebudde N","Margolis D","Hough CL","Houston J","Amaro F","Oikonomopoulo 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The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) trials.<h4>Methods</h4>A secondary analysis of 2625 adults hospitalized for acute SARS-CoV-2 infection randomized to 1 of 5 antiviral products or matched placebo in 114 centers on 4 continents. Uniform, site-level collection of participant baseline clinical variables was performed. Research laboratories assayed baseline upper respiratory swabs for SARS-CoV-2 viral RNA and plasma for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleocapsid antigen (viral Ag), and interleukin","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-01T21:56:35.056Z","creation":"2025-04-04T02:12:00.222Z"},"accession":"S-EPMC11175705","cross_references":{"pubmed":["38376212"],"doi":["10.1093/cid/ciad780"]}}