{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Campo H"],"funding":["National Institute of Environmental Health Sciences","Bill & Melinda Gates Foundation","NCCIH NIH HHS","NIEHS NIH HHS","National Cancer Institute","NCI NIH HHS","Bill and Melinda Gates Foundation"],"pagination":["4821-4833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11181516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(22)"],"pubmed_abstract":["To accurately phenocopy human biology <i>in vitro</i>, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards three-dimensional (3D) and/or multicellular culture techniques. While these culture innovations are becoming more commonplace, there is a growing body of research that illustrates the benefits and even necessity of recapitulating the dynamic flow of nutrients, gas, waste exchange and tissue interactions that occur <i>in vivo</i>. However, cost and engineering complexity are two main factors that hinder the adoption of these technologies and incorporation into standard laboratory workflows. We developed LATTICE, a plug-and-play microfluidic platform able to house up to eight large tissue or organ models that c"],"journal":["Lab on a chip"],"pubmed_title":["A new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform."],"pmcid":["PMC11181516"],"funding_grant_id":["UH3ES029073","UG3 ES029073","UH3 ES029073","INV-003385","R01 AT008824","INV-007121","R01CA243249","R01 CA243249"],"pubmed_authors":["Urbanek M","Lee HC","Zhang D","Boots CE","Kim JJ","Zhang J","Dunne SF","Ingram A","Campo H","Woodruff TK","Pavone ME","Xiao S","Colina J","Murphy A","Yoon J","Wagner S","Zha D","Pattarawat P","Burdette JE","Rogers HB","Trotter K","Russo A"],"additional_accession":[]},"is_claimable":false,"name":"A new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform.","description":"To accurately phenocopy human biology <i>in vitro</i>, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards three-dimensional (3D) and/or multicellular culture techniques. While these culture innovations are becoming more commonplace, there is a growing body of research that illustrates the benefits and even necessity of recapitulating the dynamic flow of nutrients, gas, waste exchange and tissue interactions that occur <i>in vivo</i>. However, cost and engineering complexity are two main factors that hinder the adoption of these technologies and incorporation into standard laboratory workflows. We developed LATTICE, a plug-and-play microfluidic platform able to house up to eight large tissue or organ models that c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T18:54:33.849Z","creation":"2025-04-04T18:54:33.849Z"},"accession":"S-EPMC11181516","cross_references":{"pubmed":["37846545"],"doi":["10.1039/d3lc00378g"]}}