biostudies-literatureCampo HNational Institute of Environmental Health SciencesBill & Melinda Gates FoundationNCCIH NIH HHSNIEHS NIH HHSNational Cancer InstituteNCI NIH HHSBill and Melinda Gates Foundation4821-4833https://www.ebi.ac.uk/biostudies/studies/S-EPMC11181516biostudies-literatureUnknown23(22)To accurately phenocopy human biology <i>in vitro</i>, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards three-dimensional (3D) and/or multicellular culture techniques. While these culture innovations are becoming more commonplace, there is a growing body of research that illustrates the benefits and even necessity of recapitulating the dynamic flow of nutrients, gas, waste exchange and tissue interactions that occur <i>in vivo</i>. However, cost and engineering complexity are two main factors that hinder the adoption of these technologies and incorporation into standard laboratory workflows. We developed LATTICE, a plug-and-play microfluidic platform able to house up to eight large tissue or organ models that cLab on a chipA new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform.PMC11181516UH3ES029073UG3 ES029073UH3 ES029073INV-003385R01 AT008824INV-007121R01CA243249R01 CA243249Urbanek MLee HCZhang DBoots CEKim JJZhang JDunne SFIngram ACampo HWoodruff TKPavone MEXiao SColina JMurphy AYoon JWagner SZha DPattarawat PBurdette JERogers HBTrotter KRusso AfalseA new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform.To accurately phenocopy human biology <i>in vitro</i>, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards three-dimensional (3D) and/or multicellular culture techniques. While these culture innovations are becoming more commonplace, there is a growing body of research that illustrates the benefits and even necessity of recapitulating the dynamic flow of nutrients, gas, waste exchange and tissue interactions that occur <i>in vivo</i>. However, cost and engineering complexity are two main factors that hinder the adoption of these technologies and incorporation into standard laboratory workflows. We developed LATTICE, a plug-and-play microfluidic platform able to house up to eight large tissue or organ models that c2023-01-01T00:00:00Z2023 Nov2025-04-04T18:54:33.849Z2025-04-04T18:54:33.849ZS-EPMC111815163784654510.1039/d3lc00378g