{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Trautman ME"],"funding":["BLRD VA","NIDCR NIH HHS","NIA NIH HHS","NIDDK NIH HHS","NIAAA NIH HHS","NCI NIH HHS"],"pubmed_abstract":["The amino acid composition of the diet has recently emerged as a critical regulator of metabolic health. Consumption of the branched-chain amino acid isoleucine is positively correlated with body mass index in humans, and reducing dietary levels of isoleucine rapidly improves the metabolic health of diet-induced obese male C57BL/6J mice. However, it is unknown how sex, strain, and dietary isoleucine intake may interact to impact the response to a Western Diet (WD). Here, we find that although the magnitude of the effect varies by sex and strain, reducing dietary levels of isoleucine protects C57BL/6J and DBA/2J mice of both sexes from the deleterious metabolic effects of a WD, while increasing dietary levels of isoleucine impairs aspects of metabolic health. Despite broadly positive respon"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.05.30.596340"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11185563"],"repository":["biostudies-literature"],"pubmed_title":["Dietary isoleucine content defines the metabolic and molecular response to a Western diet."],"pmcid":["PMC11185563"],"funding_grant_id":["U01 AG081482","R01 AA029124","R01 DK125859","R01 AG062328","P50 DE026787","RF1 AG056771","P30 DK020579","R01 AG056771","P30 CA014520","R56 AG056771","F31 AG081115","R01 DK133479","F32 AG077916","P50 CA278595","R01 AG084156","U54 DK104310","I01 BX004031","F99 AG083290","T32 AG000213","R01 DK131175"],"pubmed_authors":["Marshall RN","Jang C","Yeh CY","MacArthur MR","Zelenovskiy E","Babygirija R","Lamming DW","Sonsalla MM","James I","Gilpin M","Ong IM","Alam YH","Green M","Trautman ME","Green CL","Chaiyakul K","Simcox JA","Malecki KC","Flores V"],"additional_accession":[]},"is_claimable":false,"name":"Dietary isoleucine content defines the metabolic and molecular response to a Western diet.","description":"The amino acid composition of the diet has recently emerged as a critical regulator of metabolic health. Consumption of the branched-chain amino acid isoleucine is positively correlated with body mass index in humans, and reducing dietary levels of isoleucine rapidly improves the metabolic health of diet-induced obese male C57BL/6J mice. However, it is unknown how sex, strain, and dietary isoleucine intake may interact to impact the response to a Western Diet (WD). Here, we find that although the magnitude of the effect varies by sex and strain, reducing dietary levels of isoleucine protects C57BL/6J and DBA/2J mice of both sexes from the deleterious metabolic effects of a WD, while increasing dietary levels of isoleucine impairs aspects of metabolic health. Despite broadly positive respon","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-04-08T15:21:43.289Z","creation":"2025-04-04T12:47:48.653Z"},"accession":"S-EPMC11185563","cross_references":{"pubmed":["38895446"],"doi":["10.1101/2024.05.30.596340"]}}