{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(3)"],"submitter":["Chen HX"],"pubmed_abstract":["Acetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage. During the early phase of liver injury, SMF markedly reduced APAP-induced oxidative stre"],"journal":["Zoological research"],"pagination":["478-491"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11188596"],"repository":["biostudies-literature"],"pubmed_title":["Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field."],"pmcid":["PMC11188596"],"pubmed_authors":["Song C","Cheng GF","Zhang L","Guo RW","Yu B","Ji XM","Zhang X","Chen HX","Feng CL","Wang JJ","Wang Y","Chen WL","Wang XY","Xie WJ"],"additional_accession":[]},"is_claimable":false,"name":"Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.","description":"Acetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage. During the early phase of liver injury, SMF markedly reduced APAP-induced oxidative stre","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-04-04T12:47:40.853Z","creation":"2025-04-04T12:47:40.853Z"},"accession":"S-EPMC11188596","cross_references":{"pubmed":["38682430"],"doi":["10.24272/j.issn.2095-8137.2023.410"]}}