biostudies-literatureUnknown45(3)Chen HXAcetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage. During the early phase of liver injury, SMF markedly reduced APAP-induced oxidative streZoological research478-491https://www.ebi.ac.uk/biostudies/studies/S-EPMC11188596biostudies-literatureAcetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.PMC11188596Song CCheng GFZhang LGuo RWYu BJi XMZhang XChen HXFeng CLWang JJWang YChen WLWang XYXie WJfalseAcetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.Acetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage. During the early phase of liver injury, SMF markedly reduced APAP-induced oxidative stre2024-01-01T00:00:00Z2024 May2025-04-04T12:47:40.853Z2025-04-04T12:47:40.853ZS-EPMC111885963868243010.24272/j.issn.2095-8137.2023.410