{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17"],"submitter":["Day JL"],"pubmed_abstract":["<h4>Introduction</h4>The Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it is also thought to operate in postmitotic neurons. Most studies linking APC/C function to neuron biology employed perturbations of the APC/C activators, cell division cycle protein 20 (Cdc20) and Cdc20 homologue 1 (Cdh1). However, multiple lines of evidence indicate that Cdh1 and Cdc20 can function in APC/C-independent contexts, so that the effects of their perturbation cannot strictly be linked to APC/C function.<h4>Methods</h4>We therefore deleted the gene encoding Anaphase Promoting Complex 4 (APC4), a core APC/C component, in neurons cultured from conditional knockout (cKO) mice.<h4>Results</h4>Our data indicate that several previously published substrates"],"journal":["Frontiers in molecular neuroscience"],"pagination":["1352782"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11199872"],"repository":["biostudies-literature"],"pubmed_title":["Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology."],"pmcid":["PMC11199872"],"pubmed_authors":["Day JL","Tirard M","Brose N"],"additional_accession":[]},"is_claimable":false,"name":"Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology.","description":"<h4>Introduction</h4>The Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it is also thought to operate in postmitotic neurons. Most studies linking APC/C function to neuron biology employed perturbations of the APC/C activators, cell division cycle protein 20 (Cdc20) and Cdc20 homologue 1 (Cdh1). However, multiple lines of evidence indicate that Cdh1 and Cdc20 can function in APC/C-independent contexts, so that the effects of their perturbation cannot strictly be linked to APC/C function.<h4>Methods</h4>We therefore deleted the gene encoding Anaphase Promoting Complex 4 (APC4), a core APC/C component, in neurons cultured from conditional knockout (cKO) mice.<h4>Results</h4>Our data indicate that several previously published substrates","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-18T12:24:12.226Z","creation":"2024-10-15T14:20:57.597Z"},"accession":"S-EPMC11199872","cross_references":{"pubmed":["38932933"],"doi":["10.3389/fnmol.2024.1352782"]}}