{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(12)"],"submitter":["Pasquini M"],"pubmed_abstract":["<i>Odad3</i> gene loss-of-function mutation leads to Primary Ciliary Dyskinesia (PCD), a disease caused by motile cilia dysfunction. Previously, we demonstrated that knockout of the <i>Odad3</i> gene in mice replicates several features of PCD, such as hydrocephalus, defects in left-right body symmetry, and male infertility, with a complete absence of sperm in the reproductive tract. The majority of <i>Odad3</i> knockout animals die before sexual maturation due to severe hydrocephalus and failure to thrive, which precludes fertility studies. Here, we performed the expression analysis of the <i>Odad3</i> gene during gonad development and in adult testes. We showed that <i>Odad3</i> starts its expression during the first wave of spermatogenesis, specifically at the meiotic stage, and that its"],"journal":["Cells"],"pagination":["1053"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11201558"],"repository":["biostudies-literature"],"pubmed_title":["The <i>Odad3</i> Gene Is Necessary for Spermatozoa Development and Male Fertility in Mice."],"pmcid":["PMC11201558"],"pubmed_authors":["Chiani F","Pasquini M","Gambadoro A","Paoletti R","Orsini T","La Sala G","Ermakova O","Putti S","Di Pietro C","Scavizzi F"],"additional_accession":[]},"is_claimable":false,"name":"The <i>Odad3</i> Gene Is Necessary for Spermatozoa Development and Male Fertility in Mice.","description":"<i>Odad3</i> gene loss-of-function mutation leads to Primary Ciliary Dyskinesia (PCD), a disease caused by motile cilia dysfunction. Previously, we demonstrated that knockout of the <i>Odad3</i> gene in mice replicates several features of PCD, such as hydrocephalus, defects in left-right body symmetry, and male infertility, with a complete absence of sperm in the reproductive tract. The majority of <i>Odad3</i> knockout animals die before sexual maturation due to severe hydrocephalus and failure to thrive, which precludes fertility studies. Here, we performed the expression analysis of the <i>Odad3</i> gene during gonad development and in adult testes. We showed that <i>Odad3</i> starts its expression during the first wave of spermatogenesis, specifically at the meiotic stage, and that its","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-23T03:08:46.714Z","creation":"2025-04-05T17:53:46.604Z"},"accession":"S-EPMC11201558","cross_references":{"pubmed":["38920681"],"doi":["10.3390/cells13121053"]}}