{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(26)"],"submitter":["Tsokas P"],"pubmed_abstract":["How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding protein genetically linked to human memory performance, complexes with protein kinase Mzeta (PKMζ), anchoring the kinase's potentiating action to maintain late-phase long-term potentiation (late-LTP) at activated synapses. Two structurally distinct antagonists of KIBRA-PKMζ dimerization disrupt established late-LTP and long-term spatial memory, yet neither measurably affects basal synaptic transmission. Neither antagonist affects PKMζ-independent LTP or memory that are maintained by compensating PKCs in ζ-knockout mice; thus, both agents require PKMζ for their effect. KIBRA-PKMζ co"],"journal":["Science advances"],"pagination":["eadl0030"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11204205"],"repository":["biostudies-literature"],"pubmed_title":["KIBRA anchoring the action of PKMζ maintains the persistence of memory."],"pmcid":["PMC11204205"],"pubmed_authors":["Sacktor TC","Tcherepanov A","Thomas C","Bernabo M","Fenton AA","Bergold PJ","Hernandez AI","Shouval HZ","Hsieh C","Nader K","Tsokas P","Kremerskothen J","Flores-Obando RE","Cottrell JE"],"additional_accession":[]},"is_claimable":false,"name":"KIBRA anchoring the action of PKMζ maintains the persistence of memory.","description":"How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding protein genetically linked to human memory performance, complexes with protein kinase Mzeta (PKMζ), anchoring the kinase's potentiating action to maintain late-phase long-term potentiation (late-LTP) at activated synapses. Two structurally distinct antagonists of KIBRA-PKMζ dimerization disrupt established late-LTP and long-term spatial memory, yet neither measurably affects basal synaptic transmission. Neither antagonist affects PKMζ-independent LTP or memory that are maintained by compensating PKCs in ζ-knockout mice; thus, both agents require PKMζ for their effect. KIBRA-PKMζ co","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-26T22:41:51.104Z","creation":"2025-04-06T17:17:28.08Z"},"accession":"S-EPMC11204205","cross_references":{"pubmed":["38924398"],"doi":["10.1126/sciadv.adl0030"]}}