{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alaiya A"],"funding":["King Abdullah International Medical Research Center"],"pagination":["6787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11204259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(12)"],"pubmed_abstract":["Heat stroke, a hazardous hyperthermia-related illness, is characterized by CNS injury, particularly long-lasting brain damage. A root cause for hyperthermic neurological damage is heat-induced proteotoxic stress through protein aggregation, a known causative agent of neurological disorders. Stress magnitude and enduring persistence are highly correlated with hyperthermia-associated neurological damage. We used an untargeted proteomic approach using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify and characterize time-series proteome-wide changes in dose-responsive proteotoxic stress models in medulloblastoma [Daoy], neuroblastoma [SH-SY5Y], and differentiated SH-SY5Y neuron-like cells [SH(D)]. An integrated analysis of condition-time datasets identified global proteom"],"journal":["International journal of molecular sciences"],"pubmed_title":["Proteomics Analysis of Proteotoxic Stress Response in In-Vitro Human Neuronal Models."],"pmcid":["PMC11204259"],"funding_grant_id":["RC16/196"],"pubmed_authors":["Albinhassan TH","Bouchama A","Mohammad S","Shinwari Z","Rashid M","Alwesmi MB","Malik SS","Alharbi BM","Alaiya A"],"additional_accession":[]},"is_claimable":false,"name":"Proteomics Analysis of Proteotoxic Stress Response in In-Vitro Human Neuronal Models.","description":"Heat stroke, a hazardous hyperthermia-related illness, is characterized by CNS injury, particularly long-lasting brain damage. A root cause for hyperthermic neurological damage is heat-induced proteotoxic stress through protein aggregation, a known causative agent of neurological disorders. Stress magnitude and enduring persistence are highly correlated with hyperthermia-associated neurological damage. We used an untargeted proteomic approach using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify and characterize time-series proteome-wide changes in dose-responsive proteotoxic stress models in medulloblastoma [Daoy], neuroblastoma [SH-SY5Y], and differentiated SH-SY5Y neuron-like cells [SH(D)]. An integrated analysis of condition-time datasets identified global proteom","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-04-07T22:56:10.432Z","creation":"2026-04-07T18:48:11.008Z"},"accession":"S-EPMC11204259","cross_references":{"pubmed":["38928492"],"doi":["10.3390/ijms25126787"]}}