{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(1)"],"submitter":["Hua JPY"],"funding":["Department of Veterans Affairs Sierra Pacific Mental Illness Research, Education, and Clinical Center"],"pubmed_abstract":["Research has found strong evidence for common and distinct morphometric brain abnormality profiles in nonaffective psychosis (NAff-P) and affective psychosis (Aff-P). Due to chronicity and prolonged medication exposure confounds, it is crucial to examine structural morphometry early in the course of psychosis. Using Human Connectome Project-Early Psychosis data, multivariate profile analyses were implemented to examine regional profiles for cortical thickness, cortical surface area, subcortical volume, and ventricular volume in healthy control (HC; <i>n</i> = 56), early illness NAff-P (<i>n</i> = 83), and Aff-P (<i>n</i> = 30) groups after accounting for normal aging. Associations with symptom severity, functioning, and cognition were also examined. Group regional profiles were significantly nonparallel and differed in level for cortical thickness (<i>P</i> < .001), with NAff-P having widespread cortical thinning relative to HC and Aff-P and some regions showing greater deficits than others. Significant nonparallelism of group regional profiles was also evident for cortical surface area (<i>P</i> < .006), with Aff-P and N-Aff-P differing from HC and from each other (<i>P</i> < .001). For subcortical volume, there was significant profile nonparallelism with NAff-P having an enlarged left pallidum and smaller accumbens and hippocampus (<i>P</i> < .028), and Aff-P having a smaller accumbens and amygdala (<i>P</i> < .006), relative to HC. NAff-P also had larger basal ganglia compared to Aff-P. Furthermore, NAff-P had enlarged ventricles (<i>P</i> < .055) compared to HC and Aff-P. Additionally, greater ventricular volume was associated with increased manic symptoms in NAff-P and Aff-P. Overall, this study found common and distinct regional morphometric profile abnormalities in early illness NAff-P and Aff-P, providing evidence for both shared and disease-specific pathophysiological processes."],"journal":["Schizophrenia bulletin open"],"pagination":["sgac028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11206002"],"repository":["biostudies-literature"],"pubmed_title":["Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis."],"pmcid":["PMC11206002"],"pubmed_authors":["Mathalon DH","Hua JPY"],"additional_accession":[]},"is_claimable":false,"name":"Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis.","description":"Research has found strong evidence for common and distinct morphometric brain abnormality profiles in nonaffective psychosis (NAff-P) and affective psychosis (Aff-P). Due to chronicity and prolonged medication exposure confounds, it is crucial to examine structural morphometry early in the course of psychosis. Using Human Connectome Project-Early Psychosis data, multivariate profile analyses were implemented to examine regional profiles for cortical thickness, cortical surface area, subcortical volume, and ventricular volume in healthy control (HC; <i>n</i> = 56), early illness NAff-P (<i>n</i> = 83), and Aff-P (<i>n</i> = 30) groups after accounting for normal aging. Associations with symptom severity, functioning, and cognition were also examined. Group regional profiles were significantly nonparallel and differed in level for cortical thickness (<i>P</i> < .001), with NAff-P having widespread cortical thinning relative to HC and Aff-P and some regions showing greater deficits than others. Significant nonparallelism of group regional profiles was also evident for cortical surface area (<i>P</i> < .006), with Aff-P and N-Aff-P differing from HC and from each other (<i>P</i> < .001). For subcortical volume, there was significant profile nonparallelism with NAff-P having an enlarged left pallidum and smaller accumbens and hippocampus (<i>P</i> < .028), and Aff-P having a smaller accumbens and amygdala (<i>P</i> < .006), relative to HC. NAff-P also had larger basal ganglia compared to Aff-P. Furthermore, NAff-P had enlarged ventricles (<i>P</i> < .055) compared to HC and Aff-P. Additionally, greater ventricular volume was associated with increased manic symptoms in NAff-P and Aff-P. Overall, this study found common and distinct regional morphometric profile abnormalities in early illness NAff-P and Aff-P, providing evidence for both shared and disease-specific pathophysiological processes.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-06-03T12:03:26.39Z","creation":"2025-04-05T10:09:26.189Z"},"accession":"S-EPMC11206002","cross_references":{"pubmed":["39144757"],"doi":["10.1093/schizbullopen/sgac028"]}}