{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bi X"],"funding":["Natural Science Foundation of Zhejiang Province","Chinese Postdoctoral Science Foundation","National Natural Science Foundation of China"],"pagination":["294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11206149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(6)"],"pubmed_abstract":["Cardiovascular diseases are the most common causes of mortality and disability worldwide. Eicosanoids are a group of bioactive metabolites that are mainly oxidized by arachidonic acid. Eicosanoids play a diverse role in cardiovascular diseases, with some exerting beneficial effects while others have detrimental consequences. However, a causal relationship between eicosanoid levels and cardiovascular disease remains unclear. Six single nucleotide polymorphisms (SNPs) with strong associations with plasma eicosanoid levels were selected. Summary-level data for cardiovascular disease were obtained from publicly available genome-wide association studies. A two-sample MR analysis identified that plasma eicosanoid levels were inversely correlated with unstable angina pectoris (OR 1.06; 95% CI 1-1"],"journal":["Metabolites"],"pubmed_title":["Genetic Evidence for Causal Relationships between Plasma Eicosanoid Levels and Cardiovascular Disease."],"pmcid":["PMC11206149"],"funding_grant_id":["81800706","81900232","LQ19H020011","2019M652118"],"pubmed_authors":["Bi X","Wang M","Li X","Lin Y","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Evidence for Causal Relationships between Plasma Eicosanoid Levels and Cardiovascular Disease.","description":"Cardiovascular diseases are the most common causes of mortality and disability worldwide. Eicosanoids are a group of bioactive metabolites that are mainly oxidized by arachidonic acid. Eicosanoids play a diverse role in cardiovascular diseases, with some exerting beneficial effects while others have detrimental consequences. However, a causal relationship between eicosanoid levels and cardiovascular disease remains unclear. Six single nucleotide polymorphisms (SNPs) with strong associations with plasma eicosanoid levels were selected. Summary-level data for cardiovascular disease were obtained from publicly available genome-wide association studies. A two-sample MR analysis identified that plasma eicosanoid levels were inversely correlated with unstable angina pectoris (OR 1.06; 95% CI 1-1","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-07T16:17:24.425Z","creation":"2025-04-05T17:56:55.938Z"},"accession":"S-EPMC11206149","cross_references":{"pubmed":["38921429"],"doi":["10.3390/metabo14060294"]}}