biostudies-literatureVu PTNCATS NIH HHSNIBIB NIH HHSNational Institutes of HealthNIH HHS14807https://www.ebi.ac.uk/biostudies/studies/S-EPMC11208425biostudies-literatureUnknown14(1)The study of muscle mass as an imaging-derived phenotype (IDP) may yield new insights into determining the normal and pathologic variations in muscle mass in the population. This can be done by determining 3D abdominal muscle mass from 12 distinct abdominal muscle regions and groups using computed tomography (CT) in a racially diverse medical biobank. To develop a fully automatic technique for assessment of CT abdominal muscle IDPs and preliminarily determine abdominal muscle IDP variations with age and sex in a clinically and racially diverse medical biobank. This retrospective study was conducted using the Penn Medicine BioBank (PMBB), a research protocol that recruits adult participants during outpatient visits at hospitals in the Penn Medicine network. We developed a deep residual U-NeScientific reportsCT imaging-derived phenotypes for abdominal muscle and their association with age and sex in a medical biobank.PMC11208425P41 EB029460UL1 TR001878Rader DJChahine CSwago SGee JChatterjee NThompson EWWu GBradford YGershuni VIkhlas AVerma ALivingstone MDudek SVu PTLuks VNaseer NVadivieso FJudy RHu-Sain KStephanowski JPenn Medicine BiobankHaubein NPoindexter ARaghupathy PDerOhannessian SSagreiya HOteng EVerma SSMacLean MTWeaver JZielinski MRitchie MDDrivas TDuda JRisman MRader DKripke CMTran TBhattaru ATran RDunn JKo YAWitschey WRDavidson LHazim MfalseCT imaging-derived phenotypes for abdominal muscle and their association with age and sex in a medical biobank.The study of muscle mass as an imaging-derived phenotype (IDP) may yield new insights into determining the normal and pathologic variations in muscle mass in the population. This can be done by determining 3D abdominal muscle mass from 12 distinct abdominal muscle regions and groups using computed tomography (CT) in a racially diverse medical biobank. To develop a fully automatic technique for assessment of CT abdominal muscle IDPs and preliminarily determine abdominal muscle IDP variations with age and sex in a clinically and racially diverse medical biobank. This retrospective study was conducted using the Penn Medicine BioBank (PMBB), a research protocol that recruits adult participants during outpatient visits at hospitals in the Penn Medicine network. We developed a deep residual U-Ne2024-01-01T00:00:00Z2024 Jun2026-05-03T03:22:52.714Z2025-04-04T21:21:58.245ZS-EPMC112084253892647910.1038/s41598-024-64603-6